GZMM (granzyme M)

2007-02-01  

Identity

HGNC
GZMM
LOCATION
19p13.3
LOCUSID
3004
ALIAS
LMET1,MET1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3004
MIM: 600311
HGNC: 4712
Ensembl: ENSG00000197540

Variants:

dbSNP: 3004
ClinVar: 3004
TCGA: ENSG00000197540
COSMIC: GZMM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197540ENST00000264553P51124
ENSG00000197540ENST00000592501U3KQV5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Initial triggering of complementREACTOMER-HSA-166663
Alternative complement activationREACTOMER-HSA-173736

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
339537292021Cytotoxic Lymphocytes Target HIV-1 Gag Through Granzyme M-Mediated Cleavage.2
339537292021Cytotoxic Lymphocytes Target HIV-1 Gag Through Granzyme M-Mediated Cleavage.2
322828332020Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.6
322828332020Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.6
271337192016Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling.53
274416552016Granzyme M has a critical role in providing innate immune protection in ulcerative colitis.7
271337192016Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling.53
274416552016Granzyme M has a critical role in providing innate immune protection in ulcerative colitis.7
243165902014Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation.4
243165902014Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation.4
230998532013Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication.18
230998532013Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication.18
219794652012FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade.17
219794652012FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade.17
201079082011Granzyme M: characterization with sites of post-translational modification and specific sites of interaction with substrates and inhibitors.2

Citation

Dessen P

GZMM (granzyme M)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43668/gzmm-(granzyme-m)