RAB3IP (RAB3A interacting protein)

2007-02-01  

Identity

HGNC
LOCATION
12q15
LOCUSID
ALIAS
RABIN3,RABIN8
FUSION GENES

Other Information

Locus ID:

NCBI: 117177
MIM: 608686
HGNC: 16508
Ensembl: ENSG00000127328

Variants:

dbSNP: 117177
ClinVar: 117177
TCGA: ENSG00000127328
COSMIC: RAB3IP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127328ENST00000247833Q96QF0
ENSG00000127328ENST00000362025Q96QF0
ENSG00000127328ENST00000378809J3KPG1
ENSG00000127328ENST00000378815Q96QF0
ENSG00000127328ENST00000417413Q96QF0
ENSG00000127328ENST00000483530Q96QF0
ENSG00000127328ENST00000526994H0YD03
ENSG00000127328ENST00000547055H0YI66
ENSG00000127328ENST00000547591H0YHP4
ENSG00000127328ENST00000549760F8VNX9
ENSG00000127328ENST00000550536Q96QF0
ENSG00000127328ENST00000550647H0YI02
ENSG00000127328ENST00000550847F8VTR6
ENSG00000127328ENST00000551641Q96QF0
ENSG00000127328ENST00000552199Q96QF0
ENSG00000127328ENST00000553099Q96QF0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
VxPx cargo-targeting to ciliumREACTOMER-HSA-5620916
BBSome-mediated cargo-targeting to ciliumREACTOMER-HSA-5620922
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
332080532021LINC00943 knockdown attenuates MPP(+)-induced neuronal damage via miR-15b-5p/RAB3IP axis in SK-N-SH cells.7
332080532021LINC00943 knockdown attenuates MPP(+)-induced neuronal damage via miR-15b-5p/RAB3IP axis in SK-N-SH cells.7
324424772020Long noncoding RNA NEAT1 knockdown inhibits MPP(+)-induced apoptosis, inflammation and cytotoxicity in SK-N-SH cells by regulating miR-212-5p/RAB3IP axis.14
330922682020Rab8 and Rabin8-Mediated Tumor Formation by Hyperactivated EGFR Signaling via FGFR Signaling.3
324424772020Long noncoding RNA NEAT1 knockdown inhibits MPP(+)-induced apoptosis, inflammation and cytotoxicity in SK-N-SH cells by regulating miR-212-5p/RAB3IP axis.14
330922682020Rab8 and Rabin8-Mediated Tumor Formation by Hyperactivated EGFR Signaling via FGFR Signaling.3
314670832019The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.15
314670832019The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.15
293186572018Crystal structure of tetrameric human Rabin8 GEF domain.2
300058702018Rab3IP interacts with SSX2 and enhances the invasiveness of gastric cancer cells.6
293186572018Crystal structure of tetrameric human Rabin8 GEF domain.2
300058702018Rab3IP interacts with SSX2 and enhances the invasiveness of gastric cancer cells.6
255353872015Activation of Rab8 guanine nucleotide exchange factor Rabin8 by ERK1/2 in response to EGF signaling.24
256738792015The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting.30
257872722015Rabin8 suppresses autophagosome formation independently of its guanine nucleotide-exchange activity towards Rab8.7

Citation

Dessen P

RAB3IP (RAB3A interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43670/rab3ip-(rab3a-interacting-protein)