GLRX (glutaredoxin)

2007-02-01  

Identity

HGNC
GLRX
LOCATION
5q15
LOCUSID
2745
ALIAS
GRX,GRX1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2745
MIM: 600443
HGNC: 4330
Ensembl: ENSG00000173221

Variants:

dbSNP: 2745
ClinVar: 2745
TCGA: ENSG00000173221
COSMIC: GLRX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173221ENST00000237858P35754
ENSG00000173221ENST00000237858A0A024RAM2
ENSG00000173221ENST00000379979P35754
ENSG00000173221ENST00000379979A0A024RAM2
ENSG00000173221ENST00000505427P35754
ENSG00000173221ENST00000505427A0A024RAM2
ENSG00000173221ENST00000508780P35754
ENSG00000173221ENST00000508780A0A024RAM2
ENSG00000173221ENST00000512469P35754
ENSG00000173221ENST00000512469A0A024RAM2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
122441062002Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2.74
171856282007Glutathiolation regulates tumor necrosis factor-alpha-induced caspase-3 cleavage and apoptosis: key role for glutaredoxin in the death pathway.69
127239712003Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1.52
192650392009Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674.51
229772472012Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose.49
163115082006Involvement of glutaredoxin-1 and thioredoxin-1 in beta-amyloid toxicity and Alzheimer's disease.44
118324872002Glutaredoxin-dependent peroxiredoxin from poplar: protein-protein interaction and catalytic mechanism.41
125564672003Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase). Potential role in redox signal transduction.41
195788762009The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.39
170644122006Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease.37

Citation

Dessen P

GLRX (glutaredoxin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43676/glrx-(glutaredoxin)