SLC16A4 (solute carrier family 16 member 4)

2007-02-01  

Identity

HGNC
LOCATION
1p13.3
LOCUSID
ALIAS
MCT4,MCT5

Other Information

Locus ID:

NCBI: 9122
MIM: 603878
HGNC: 10925
Ensembl: ENSG00000168679

Variants:

dbSNP: 9122
ClinVar: 9122
TCGA: ENSG00000168679
COSMIC: SLC16A4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168679ENST00000369779O15374
ENSG00000168679ENST00000369781O15374
ENSG00000168679ENST00000437429O15374
ENSG00000168679ENST00000461647E9PKZ1
ENSG00000168679ENST00000467986H0YEG4
ENSG00000168679ENST00000472422O15374
ENSG00000168679ENST00000492412E9PKZ1
ENSG00000168679ENST00000528649E9PRV1
ENSG00000168679ENST00000541986O15374

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164524782006The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.242
215588142011Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.152
219309172011CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.137
159172402005Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70).90
181885952008Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.80
232588462013Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.78
235747252013Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer.70
204546402010Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44.67
218703312011GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression.67
217873882011Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer.57

Citation

Dessen P

SLC16A4 (solute carrier family 16 member 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43681/slc16a4-(solute-carrier-family-16-member-4)