Identity
HGNC
LOCATION
12p13.33
LOCUSID
ALIAS
CACH2,CACN2,CACNL1A1,CCHL1A1,CaV1.2,LQT8,TS,TS.
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 775
MIM: 114205
HGNC: 1390
Ensembl: ENSG00000151067
Variants:
dbSNP: 775
ClinVar: 775
TCGA: ENSG00000151067
COSMIC: CACNA1C
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10407 | calcium channel blockers | Chemical | ClinicalAnnotation | associated | PD | 16610939 | |
| PA166151827 | adverse events | Disease | ClinicalAnnotation | associated | PD | 28391406 | |
| PA33748 | PRKACA | Gene | Pathway | associated | |||
| PA33749 | PRKACB | Gene | Pathway | associated | |||
| PA33750 | PRKACG | Gene | Pathway | associated | |||
| PA443309 | Alcoholism | Disease | ClinicalAnnotation | associated | PD | 31634677 | |
| PA443796 | Coronary Artery Disease | Disease | ClinicalAnnotation | associated | PD | 20031608 | |
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 16610939, 20031608 | |
| PA444704 | Premature Birth | Disease | ClinicalAnnotation | associated | PD | 28391406 | |
| PA447199 | Bipolar Disorder | Disease | ClinicalAnnotation, Literature, MultilinkAnnotation | associated | PD | 24718920, 31634677 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 19388002 | |
| PA448073 | ethanol | Chemical | ClinicalAnnotation | associated | PD | 31634677 | |
| PA448499 | atenolol | Chemical | ClinicalAnnotation | associated | PD | 20031608 | |
| PA448871 | celecoxib | Chemical | Pathway | associated | 22336956 | ||
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD | 19388002 | |
| PA449841 | haloperidol | Chemical | MultilinkAnnotation | associated | 27023437 | ||
| PA450633 | nimodipine | Chemical | ClinicalAnnotation | associated | PD | 19205682 | |
| PA451258 | ritodrine | Chemical | ClinicalAnnotation | associated | PD | 28391406 | |
| PA451846 | valproic acid | Chemical | Pathway | associated | 23407051 | ||
| PA451868 | verapamil | Chemical | ClinicalAnnotation | associated | PD | 20031608 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38657895 | 2024 | Effects of CACNA1C and ANK3 on cognitive function in patients with bipolar disorder. | 0 |
| 38657895 | 2024 | Effects of CACNA1C and ANK3 on cognitive function in patients with bipolar disorder. | 0 |
| 35128618 | 2023 | BDNF Levels According to Variations in the CACNA1C Gene: Sex-Based Disparity. | 0 |
| 35786202 | 2023 | Impact of ZNF804A rs1344706 or CACNA1C rs1006737 polymorphisms on cognition in patients with severe mental disorders: A systematic review and meta-analysis. | 3 |
| 36436328 | 2023 | A Cross-Sectional Study of the Neuropsychiatric Phenotype of CACNA1C-Related Disorder. | 3 |
| 36598608 | 2023 | CACNA1C-Related Channelopathies. | 4 |
| 37009738 | 2023 | Phenotypic Characterization of Timothy Syndrome Caused by the CACNA1C p.Gly402Ser Variant. | 2 |
| 37196677 | 2023 | EMC chaperone-Ca(V) structure reveals an ion channel assembly intermediate. | 11 |
| 37489644 | 2023 | The rs216009 single-nucleotide polymorphism of the CACNA1C gene is associated with phantom tooth pain. | 0 |
| 37493923 | 2023 | Effect of rs1108580 of DBH and rs1006737 of CACNA1C on Cognition and Tardive Dyskinesia in a North Indian Schizophrenia Cohort. | 0 |
| 37706495 | 2023 | A novel risk variant block across introns 36-45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study. | 0 |
| 37972591 | 2023 | Structural basis for human Ca(v)1.2 inhibition by multiple drugs and the neurotoxin calciseptine. | 5 |
| 35128618 | 2023 | BDNF Levels According to Variations in the CACNA1C Gene: Sex-Based Disparity. | 0 |
| 35786202 | 2023 | Impact of ZNF804A rs1344706 or CACNA1C rs1006737 polymorphisms on cognition in patients with severe mental disorders: A systematic review and meta-analysis. | 3 |
| 36436328 | 2023 | A Cross-Sectional Study of the Neuropsychiatric Phenotype of CACNA1C-Related Disorder. | 3 |
Citation
Dessen P
CACNA1C (calcium voltage-gated channel subunit alpha1 C)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43691/cacna1c-(calcium-voltage-gated-channel-subunit-alpha1-c)
