Identity
HGNC
LOCATION
18q23
LOCUSID
ALIAS
NF-ATC,NF-ATc1.2,NFAT2,NFATc
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4772
MIM: 600489
HGNC: 7775
Ensembl: ENSG00000131196
Variants:
dbSNP: 4772
ClinVar: 4772
TCGA: ENSG00000131196
COSMIC: NFATC1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA33678 | PPP3CA | Gene | Pathway | associated | 23922006 | ||
| PA33679 | PPP3CB | Gene | Pathway | associated | 23922006 | ||
| PA33680 | PPP3CC | Gene | Pathway | associated | 23922006 | ||
| PA33681 | PPP3R1 | Gene | Pathway | associated | 23922006 | ||
| PA33682 | PPP3R2 | Gene | Pathway | associated | 23922006 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37758852 | 2024 | Clinical value of echocardiography combined with serum Cav-1, NFATc1, and PAI-1 in the diagnosis of Kawasaki disease complicated with coronary artery lesions. | 0 |
| 38310228 | 2024 | Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets. | 0 |
| 37758852 | 2024 | Clinical value of echocardiography combined with serum Cav-1, NFATc1, and PAI-1 in the diagnosis of Kawasaki disease complicated with coronary artery lesions. | 0 |
| 38310228 | 2024 | Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets. | 0 |
| 36680554 | 2023 | Risk Variants in or Near ZBTB40 AND NFATC1 Increase the Risk of Both IBD and Adverse Bone Health Outcomes Highlighting Common Genetic Underpinnings Across Both Diseases. | 0 |
| 36766846 | 2023 | NFATc1 Regulation of Dexamethasone-Induced TGFB2 Expression Is Cell Cycle Dependent in Trabecular Meshwork Cells. | 1 |
| 37248542 | 2023 | Human bone marrow-derived mesenchymal stem overexpressing microRNA-124-3p inhibit DLBCL progression by downregulating the NFATc1/cMYC pathway. | 2 |
| 37249233 | 2023 | Biallelic NFATC1 mutations cause an inborn error of immunity with impaired CD8+ T-cell function and perturbed glycolysis. | 1 |
| 37342957 | 2023 | Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency. | 2 |
| 37347664 | 2023 | NFAT and NF-κB dynamically co-regulate TCR and CAR signaling responses in human T cells. | 6 |
| 37392543 | 2023 | SIRT3-and FAK-mediated acetylation-phosphorylation crosstalk of NFATc1 regulates N(ε)-carboxymethyl-lysine-induced vascular calcification in diabetes mellitus. | 1 |
| 37535148 | 2023 | USP7-mediated JUND suppresses RCAN2 transcription and elevates NFATC1 to enhance stem cell property in colorectal cancer. | 1 |
| 37814550 | 2023 | The role of NFATc1 in the progression and metastasis of prostate cancer: A review on the molecular mechanisms and signaling pathways. | 0 |
| 37957146 | 2023 | Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption. | 3 |
| 36680554 | 2023 | Risk Variants in or Near ZBTB40 AND NFATC1 Increase the Risk of Both IBD and Adverse Bone Health Outcomes Highlighting Common Genetic Underpinnings Across Both Diseases. | 0 |
Citation
Dessen P
NFATC1 (nuclear factor of activated T cells 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43698/nfatc1-(nuclear-factor-of-activated-t-cells-1)
