STAT1 (signal transducer and activator of transcription 1)

2003-02-01 Affiliation

Identity

HGNC

STAT1

LOCATION

2q32.2

LOCUSID

6772

ALIAS

CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT91

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6772
MIM: 600555
HGNC: 11362
Ensembl: ENSG00000115415

Variants:

dbSNP: 6772
ClinVar: 6772
TCGA: ENSG00000115415
COSMIC: STAT1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115415	ENST00000361099	P42224
ENSG00000115415	ENST00000392322	P42224
ENSG00000115415	ENST00000392323	J3KPM9
ENSG00000115415	ENST00000409465	P42224
ENSG00000115415	ENST00000415035	H7BZ88
ENSG00000115415	ENST00000423282	H7BZB5
ENSG00000115415	ENST00000423282	Q67C41
ENSG00000115415	ENST00000424722	E7EPD2
ENSG00000115415	ENST00000432058	E9PH66
ENSG00000115415	ENST00000452281	D2KFR9
ENSG00000115415	ENST00000454414	E7ENM1
ENSG00000115415	ENST00000540176	D2KFR9

Expression (GTEx)

100

200

300

400

500

600

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Toll-like receptor signaling pathway	KEGG	ko04620
Jak-STAT signaling pathway	KEGG	ko04630
Pancreatic cancer	KEGG	ko05212
Toll-like receptor signaling pathway	KEGG	hsa04620
Jak-STAT signaling pathway	KEGG	hsa04630
Pathways in cancer	KEGG	hsa05200
Pancreatic cancer	KEGG	hsa05212
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Hepatitis B	KEGG	hsa05161
Prolactin signaling pathway	KEGG	hsa04917
Prolactin signaling pathway	KEGG	ko04917
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
Thyroid hormone signaling pathway	KEGG	hsa04919
JAK-STAT signaling	KEGG	hsa_M00684
JAK-STAT signaling	KEGG	M00684
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by FGFR in disease	REACTOME	R-HSA-1226099
Signaling by FGFR1 in disease	REACTOME	R-HSA-5655302
FGFR1 mutant receptor activation	REACTOME	R-HSA-1839124
Signaling by cytosolic FGFR1 fusion mutants	REACTOME	R-HSA-1839117
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon alpha/beta signaling	REACTOME	R-HSA-909733
Regulation of IFNA signaling	REACTOME	R-HSA-912694
Interferon gamma signaling	REACTOME	R-HSA-877300
Regulation of IFNG signaling	REACTOME	R-HSA-877312
Antiviral mechanism by IFN-stimulated genes	REACTOME	R-HSA-1169410
ISG15 antiviral mechanism	REACTOME	R-HSA-1169408
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-6 signaling	REACTOME	R-HSA-1059683
Growth hormone receptor signaling	REACTOME	R-HSA-982772
Signal Transduction	REACTOME	R-HSA-162582
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
Interleukin-6 family signaling	REACTOME	R-HSA-6783589
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA134992438	CAMK1D	Gene	Pathway	associated
PA24684	AKT1	Gene	Pathway	associated
PA24685	AKT2	Gene	Pathway	associated
PA24686	AKT3	Gene	Pathway	associated
PA248	NFKB1	Gene	Pathway	associated
PA26048	CAMK1	Gene	Pathway	associated
PA26049	CAMK1G	Gene	Pathway	associated
PA27749	ELK1	Gene	Pathway	associated
PA28212	FOS	Gene	Pathway	associated
PA283	MAPK8	Gene	Pathway	associated
PA296	RELA	Gene	Pathway	associated
PA29988	JAK1	Gene	Pathway	associated
PA30006	JUN	Gene	Pathway	associated
PA30616	MAPK1	Gene	Pathway	associated
PA30622	MAPK3	Gene	Pathway	associated
PA31353	MYC	Gene	Pathway	associated
PA31600	NFKB2	Gene	Pathway	associated
PA33285	PIAS1	Gene	Pathway	associated	26111151
PA337	STAT3	Gene	Pathway	associated
PA33759	PRKCA	Gene	Pathway	associated
PA33761	PRKCB	Gene	Pathway	associated
PA33766	PRKCG	Gene	Pathway	associated
PA338	STAT5A	Gene	Pathway	associated
PA36042	SP1	Gene	Pathway	associated
PA36184	STAT2	Gene	Pathway	associated
PA36185	STAT4	Gene	Pathway	associated
PA36186	STAT5B	Gene	Pathway	associated
PA90	CAMK2A	Gene	Pathway	associated
PA91	CAMK2B	Gene	Pathway	associated
PA92	CAMK2D	Gene	Pathway	associated
PA93	CAMK2G	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
38047403	2024	LOXL4 Shuttled by Tumor Cells-derived Extracellular Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by Activating the STAT1/PD-L1 Axis.	1
38084635	2024	Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research.	2
38092960	2024	RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote ROS-mediated NF-κB activation and ovarian cancer progression.	4
38166970	2024	AIM2 promotes irradiation resistance, migration ability and PD-L1 expression through STAT1/NF-κB activation in oral squamous cell carcinoma.	1
38246175	2024	[Knockdown of interferon-γ inducible protein 30 (IFI30) inhibits the proliferation, invasion and migration of human glioma U251 cells by activating STAT1 and promotes their apoptosis].	0
38351096	2024	HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression.	0
38410923	2024	hsa_circ_0087100/hsa-miR-6743-5p affects Th1 cell differentiation by regulating STAT1 in diabetic retinopathy.	1
38509096	2024	Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer.	2
38640981	2024	STAT1 mediated downregulation of the tumor suppressor gene PDCD4, is driven by the atypical cadherin FAT1, in glioblastoma.	0
38706215	2024	USP39 Promotes the Viability and Migration of Head and Neck Squamous Cell Carcinoma Cell by Regulating STAT1.	0
38758476	2024	Qualitative Immunoglobulin Deficiency Causes Bacterial Infections in Patients with STAT1 Gain-of-Function Mutations.	0
38797155	2024	KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.	0
38812060	2024	Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma.	1
38869352	2024	AIM2 inflammasome regulated by the IFN-γ/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease.	0
38047403	2024	LOXL4 Shuttled by Tumor Cells-derived Extracellular Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by Activating the STAT1/PD-L1 Axis.	1

Citation

Dessen P

STAT1 (signal transducer and activator of transcription 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/437/stat1-(signal-transducer-and-activator-of-transcription-1)