GPX7 (glutathione peroxidase 7)

2007-02-01

Identity

HGNC

GPX7

LOCATION

1p32.3

LOCUSID

2882

ALIAS

CL683,GPX6,GPx-7,GSHPx-7,NPGPx

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2882
MIM: 615784
HGNC: 4559
Ensembl: ENSG00000116157

Variants:

dbSNP: 2882
ClinVar: 2882
TCGA: ENSG00000116157
COSMIC: GPX7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000116157	ENST00000361314	Q96SL4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arachidonic acid metabolism	KEGG	ko00590
Arachidonic acid metabolism	KEGG	hsa00590
Cellular responses to stress	REACTOME	R-HSA-2262752
Detoxification of Reactive Oxygen Species	REACTOME	R-HSA-3299685
Glutathione metabolism	KEGG	ko00480
Glutathione metabolism	KEGG	hsa00480
Thyroid hormone synthesis	KEGG	hsa04918
Thyroid hormone synthesis	KEGG	ko04918

Previous1Next

References

Pubmed ID	Year	Title	Citations
23580780	2014	Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma.	24
25586538	2015	Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients.	28
25586538	2015	Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients.	28
26708178	2015	GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues.	54
26708178	2015	GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues.	54
32719007	2020	Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding.	16
32719007	2020	Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding.	16
34339889	2021	MicroRNAs mediated regulation of glutathione peroxidase 7 expression and its changes during adipogenesis.	6
34339889	2021	MicroRNAs mediated regulation of glutathione peroxidase 7 expression and its changes during adipogenesis.	6
34626080	2021	GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR Pathway.	15

Previous1 2Next

Citation

Dessen P

GPX7 (glutathione peroxidase 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43719/gpx7-(glutathione-peroxidase-7)