GPX7 (glutathione peroxidase 7)

2007-02-01  

Identity

HGNC
GPX7
LOCATION
1p32.3
LOCUSID
2882
ALIAS
CL683,GPX6,GPx-7,GSHPx-7,NPGPx
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2882
MIM: 615784
HGNC: 4559
Ensembl: ENSG00000116157

Variants:

dbSNP: 2882
ClinVar: 2882
TCGA: ENSG00000116157
COSMIC: GPX7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116157ENST00000361314Q96SL4

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Arachidonic acid metabolismKEGGko00590
Glutathione metabolismKEGGhsa00480
Arachidonic acid metabolismKEGGhsa00590
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685

References

Pubmed IDYearTitleCitations
387573392024GPX7 reduces chondrocyte inflammation and extracellular matrix degradation triggered by IL‑1β, via a mechanism mediated by ferroptosis.1
387573392024GPX7 reduces chondrocyte inflammation and extracellular matrix degradation triggered by IL‑1β, via a mechanism mediated by ferroptosis.1
354407012022Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas.4
354407012022Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas.4
343398892021MicroRNAs mediated regulation of glutathione peroxidase 7 expression and its changes during adipogenesis.6
346260802021GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR Pathway.15
343398892021MicroRNAs mediated regulation of glutathione peroxidase 7 expression and its changes during adipogenesis.6
346260802021GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR Pathway.15
327190072020Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding.16
327190072020Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding.16
255865382015Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients.28
267081782015GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues.54
255865382015Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients.28
267081782015GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues.54
235807802014Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma.24

Citation

Dessen P

GPX7 (glutathione peroxidase 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43719/gpx7-(glutathione-peroxidase-7)