SLC2A1 (solute carrier family 2 member 1)

2007-02-01 Affiliation

Identity

HGNC

SLC2A1

LOCATION

1p34.2

LOCUSID

6513

ALIAS

CSE,DYT17,DYT18,DYT9,EIG12,GLUT,GLUT-1,GLUT1,GLUT1DS,HTLVR,PED,SDCHCN

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6513
MIM: 138140
HGNC: 11005
Ensembl: ENSG00000117394

Variants:

dbSNP: 6513
ClinVar: 6513
TCGA: ENSG00000117394
COSMIC: SLC2A1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000117394	ENST00000372500	A6NL68
ENSG00000117394	ENST00000426263	P11166
ENSG00000117394	ENST00000460369	A0A1W2PQ59
ENSG00000117394	ENST00000475162	A0A0D9SG74
ENSG00000117394	ENST00000630287	A0A0D9SFK9
ENSG00000117394	ENST00000669445	A0A590UJ26

Expression (GTEx)

100

200

300

400

500

600

700

800

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Adipocytokine signaling pathway	KEGG	ko04920
Renal cell carcinoma	KEGG	ko05211
Adipocytokine signaling pathway	KEGG	hsa04920
Pathways in cancer	KEGG	hsa05200
Renal cell carcinoma	KEGG	hsa05211
Bile secretion	KEGG	ko04976
Bile secretion	KEGG	hsa04976
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
HIF-1 signaling pathway	KEGG	hsa04066
Insulin secretion	KEGG	hsa04911
Thyroid hormone signaling pathway	KEGG	hsa04919
Central carbon metabolism in cancer	KEGG	hsa05230
Central carbon metabolism in cancer	KEGG	ko05230
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Hexose transport	REACTOME	R-HSA-189200
Glucose transport	REACTOME	R-HSA-70153
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Facilitative Na+-independent glucose transporters	REACTOME	R-HSA-428790
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Lactose synthesis	REACTOME	R-HSA-5653890
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Metabolism of vitamins and cofactors	REACTOME	R-HSA-196854
Metabolism of water-soluble vitamins and cofactors	REACTOME	R-HSA-196849
Vitamin C (ascorbate) metabolism	REACTOME	R-HSA-196836
Insulin resistance	KEGG	hsa04931

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21317389	2011	Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.	546
24847886	2014	Crystal structure of the human glucose transporter GLUT1.	168
23453806	2013	AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.	150
14622599	2003	The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV.	144
19286567	2009	GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis.	88
21707071	2011	Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.	85
18177733	2008	GLUT1 and GLUT9 as major contributors to glucose influx in HepG2 cells identified by a high sensitivity intramolecular FRET glucose sensor.	84
22282454	2013	Striatal presynaptic dopamine in schizophrenia, part II: meta-analysis of [(18)F/(11)C]-DOPA PET studies.	68
21870331	2011	GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression.	67
22270867	2012	Expression of GLUT1 and GLUT3 glucose transporters in endometrial and breast cancers.	64

Citation

Dessen P

SLC2A1 (solute carrier family 2 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43725/slc2a1-(solute-carrier-family-2-member-1)