Identity
HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
D2S69E,LAG-2,LAG2,NKG5,TLA519
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10578
MIM: 188855
HGNC: 4414
Ensembl: ENSG00000115523
Variants:
dbSNP: 10578
ClinVar: 10578
TCGA: ENSG00000115523
COSMIC: GNLY
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000115523 | ENST00000263863 | P22749 |
| ENSG00000115523 | ENST00000409696 | P22749 |
| ENSG00000115523 | ENST00000524600 | B4E3H9 |
| ENSG00000115523 | ENST00000526018 | H0YDW8 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Antimicrobial peptides | REACTOME | R-HSA-6803157 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38471344 | 2024 | Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome. | 0 |
| 38471344 | 2024 | Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome. | 0 |
| 35066979 | 2022 | GNLY gene polymorphism: A potential role in understanding psoriasis pathogenesis. | 3 |
| 35066979 | 2022 | GNLY gene polymorphism: A potential role in understanding psoriasis pathogenesis. | 3 |
| 33560872 | 2021 | The Role of IL-13, IL-15 and Granulysin in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. | 9 |
| 34093532 | 2021 | A Profound Membrane Reorganization Defines Susceptibility of Plasmodium falciparum Infected Red Blood Cells to Lysis by Granulysin and Perforin. | 5 |
| 34445098 | 2021 | Gran1: A Granulysin-Derived Peptide with Potent Activity against Intracellular Mycobacterium tuberculosis. | 10 |
| 34691030 | 2021 | Identification of Diagnostic Signatures and Immune Cell Infiltration Characteristics in Rheumatoid Arthritis by Integrating Bioinformatic Analysis and Machine-Learning Strategies. | 19 |
| 33560872 | 2021 | The Role of IL-13, IL-15 and Granulysin in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. | 9 |
| 34093532 | 2021 | A Profound Membrane Reorganization Defines Susceptibility of Plasmodium falciparum Infected Red Blood Cells to Lysis by Granulysin and Perforin. | 5 |
| 34445098 | 2021 | Gran1: A Granulysin-Derived Peptide with Potent Activity against Intracellular Mycobacterium tuberculosis. | 10 |
| 34691030 | 2021 | Identification of Diagnostic Signatures and Immune Cell Infiltration Characteristics in Rheumatoid Arthritis by Integrating Bioinformatic Analysis and Machine-Learning Strategies. | 19 |
| 32066596 | 2020 | γδ T Cells Kill Plasmodium falciparum in a Granzyme- and Granulysin-Dependent Mechanism during the Late Blood Stage. | 21 |
| 32271478 | 2020 | Association between seminal granulysin and malondialdehyde in infertile men with varicocele and the potential effect of varicocelectomy. | 2 |
| 32511236 | 2020 | Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli. | 30 |
Citation
Dessen P
GNLY (granulysin)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43730/gnly-(granulysin)
