KMT5C (lysine methyltransferase 5C)

2015-11-01  

Identity

HGNC
KMT5C
LOCATION
19q13.42
LOCUSID
84787
ALIAS
SUV420H2,Suv4-20h2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84787
MIM: 613198
HGNC: 28405
Ensembl: ENSG00000133247

Variants:

dbSNP: 84787
ClinVar: 84787
TCGA: ENSG00000133247
COSMIC: KMT5C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133247ENST00000255613Q86Y97
ENSG00000133247ENST00000445196Q86Y97
ENSG00000133247ENST00000592631Q86Y97
ENSG00000133247ENST00000630497A0A0D9SF94

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
384266052024Lysine methyltransferase 5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis.0
384737452024Impact of Histone Lysine Methyltransferase SUV4-20H2 on Cancer Onset and Progression with Therapeutic Potential.0
384266052024Lysine methyltransferase 5C increases the proliferation and metastatic abilities of clear cell renal cell carcinoma via aerobic glycolysis.0
384737452024Impact of Histone Lysine Methyltransferase SUV4-20H2 on Cancer Onset and Progression with Therapeutic Potential.0
364021922023Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided Colon Cancer Progression.4
371197642023Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma.1
364021922023Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided Colon Cancer Progression.4
371197642023Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma.1
354044062022Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET.19
354044062022Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET.19
331443972020H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells.13
331443972020H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells.13
292297512018SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.24
292297512018SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.24
278622262017Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation.15

Citation

Dessen P

KMT5C (lysine methyltransferase 5C)

Atlas Genet Cytogenet Oncol Haematol. 2015-11-01

Online version: http://atlasgeneticsoncology.org/gene/43731/kmt5c-(lysine-methyltransferase-5c)