HCFC1 (host cell factor C1)

2007-02-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
ALIAS
CFF,HCF,HCF-1,HCF1,HFC1,MRX3,PPP1R89,VCAF
FUSION GENES

Other Information

Locus ID:

NCBI: 3054
MIM: 300019
HGNC: 4839
Ensembl: ENSG00000172534

Variants:

dbSNP: 3054
ClinVar: 3054
TCGA: ENSG00000172534
COSMIC: HCFC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172534ENST00000310441P51610
ENSG00000172534ENST00000369984A6NEM2
ENSG00000172534ENST00000444191H7C1C4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

References

Pubmed IDYearTitleCitations
159313892005Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.297
126708682003Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.193
176124942007E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.124
200188522010Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.97
212956982011O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1.94
208053572010The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression.92
228832322012O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability.90
198155552009The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
175789102007The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection.72

Citation

Dessen P

HCFC1 (host cell factor C1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43736/hcfc1-(host-cell-factor-c1)