Identity
HGNC
LOCATION
20p11.21
LOCUSID
ALIAS
HNF-3-beta,HNF3B,TCF3B
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3170
MIM: 600288
HGNC: 5022
Ensembl: ENSG00000125798
Variants:
dbSNP: 3170
ClinVar: 3170
TCGA: ENSG00000125798
COSMIC: FOXA2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000125798 | ENST00000377115 | Q9Y261 |
| ENSG00000125798 | ENST00000419308 | Q9Y261 |
| ENSG00000125798 | ENST00000419308 | B0ZTD4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37665156 | 2024 | FOXA2 suppresses gallbladder carcinoma cell migration, invasion, and epithelial-mesenchymal transition by targeting SERPINB5. | 2 |
| 37914145 | 2024 | SENP1 knockdown-mediated CTCF SUMOylation enhanced its stability and alleviated lipopolysaccharide-evoked inflammatory injury in human lung fibroblasts via regulation of FOXA2 transcription. | 1 |
| 38072043 | 2024 | FOXA2 activates HIF2α expression to promote tumor progression and is regulated by the E3 ubiquitin ligase VHL in renal cell carcinoma. | 0 |
| 38141134 | 2024 | Analysis of GATA3 and FOXA2 expression suggests that downregulation of genes involved in the maintenance of a mature yolk sac tumor phenotype may underlie sarcomatoid transformation. | 0 |
| 38252148 | 2024 | FOXA2-initiated transcriptional activation of INHBA induced by methylmalonic acid promotes pancreatic neuroendocrine neoplasm progression. | 0 |
| 38605124 | 2024 | Chromosome 20p11.2 deletions cause congenital hyperinsulinism via the loss of FOXA2 or its regulatory elements. | 1 |
| 37665156 | 2024 | FOXA2 suppresses gallbladder carcinoma cell migration, invasion, and epithelial-mesenchymal transition by targeting SERPINB5. | 2 |
| 37914145 | 2024 | SENP1 knockdown-mediated CTCF SUMOylation enhanced its stability and alleviated lipopolysaccharide-evoked inflammatory injury in human lung fibroblasts via regulation of FOXA2 transcription. | 1 |
| 38072043 | 2024 | FOXA2 activates HIF2α expression to promote tumor progression and is regulated by the E3 ubiquitin ligase VHL in renal cell carcinoma. | 0 |
| 38141134 | 2024 | Analysis of GATA3 and FOXA2 expression suggests that downregulation of genes involved in the maintenance of a mature yolk sac tumor phenotype may underlie sarcomatoid transformation. | 0 |
| 38252148 | 2024 | FOXA2-initiated transcriptional activation of INHBA induced by methylmalonic acid promotes pancreatic neuroendocrine neoplasm progression. | 0 |
| 38605124 | 2024 | Chromosome 20p11.2 deletions cause congenital hyperinsulinism via the loss of FOXA2 or its regulatory elements. | 1 |
| 36515690 | 2023 | FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cells. | 3 |
| 36576135 | 2023 | Forkhead box A2-mediated lncRNA SOX2OT up-regulation alleviates oxidative stress and apoptosis of renal tubular epithelial cells by promoting SIRT1 expression in diabetic nephropathy. | 2 |
| 36823043 | 2023 | FOXA2 plays a critical role in hepatocellular carcinoma progression and lenvatinib-associated drug resistance. | 1 |
Citation
Dessen P
FOXA2 (forkhead box A2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43740/foxa2-(forkhead-box-a2)
