Identity
HGNC
LOCATION
8p23.1
LOCUSID
ALIAS
ASD2,TACHD,TOF,VSD1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2626
MIM: 600576
HGNC: 4173
Ensembl: ENSG00000136574
Variants:
dbSNP: 2626
ClinVar: 2626
TCGA: ENSG00000136574
COSMIC: GATA4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712718 | Drugs used in alcohol dependence | Chemical | ClinicalAnnotation | associated | PD | 20585342 | |
| PA443309 | Alcoholism | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 20585342, 29415147 | |
| PA448073 | ethanol | Chemical | VariantAnnotation | not associated | PD | 29415147 | |
| PA451906 | warfarin | Chemical | ClinicalAnnotation | associated | PD | 25026456, 29298995 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38605949 | 2024 | Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNα production. | 0 |
| 38653973 | 2024 | GATA4 regulates the transcription of MMP9 to suppress the invasion and migration of breast cancer cells via HDAC1-mediated p65 deacetylation. | 1 |
| 38605949 | 2024 | Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNα production. | 0 |
| 38653973 | 2024 | GATA4 regulates the transcription of MMP9 to suppress the invasion and migration of breast cancer cells via HDAC1-mediated p65 deacetylation. | 1 |
| 36519469 | 2023 | Bicuspid Aortic Valve-Associated Regulatory Regions Reveal GATA4 Regulation and Function During Human-Induced Pluripotent Stem Cell-Based Endothelial-Mesenchymal Transition-Brief Report. | 0 |
| 36630917 | 2023 | GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology. | 8 |
| 36804620 | 2023 | Oncogenic SIRT7 inhibits GATA4 transcriptional activity and activates the Wnt signaling pathway in ovarian cancer. | 5 |
| 36809766 | 2023 | Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease. | 2 |
| 37372326 | 2023 | Potential Prognostic Value of GATA4 Depends on the p53 Expression in Primary Glioblastoma Patients. | 0 |
| 37451139 | 2023 | GATA4 inhibits odontoblastic differentiation of dental pulp stem cells through targeting IGFBP3. | 0 |
| 37635136 | 2023 | GATA4 rs61277615, rs73203482, and rs35813172 in Newborns with Transposition of the Great Arteries. | 0 |
| 37712274 | 2023 | [High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4]. | 0 |
| 36519469 | 2023 | Bicuspid Aortic Valve-Associated Regulatory Regions Reveal GATA4 Regulation and Function During Human-Induced Pluripotent Stem Cell-Based Endothelial-Mesenchymal Transition-Brief Report. | 0 |
| 36630917 | 2023 | GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology. | 8 |
| 36804620 | 2023 | Oncogenic SIRT7 inhibits GATA4 transcriptional activity and activates the Wnt signaling pathway in ovarian cancer. | 5 |
Citation
Dessen P
GATA4 (GATA binding protein 4)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43765/gata4-(gata-binding-protein-4)
