CACYBP (calcyclin binding protein)

2007-02-01  

Identity

HGNC
LOCATION
1q25.1
LOCUSID
ALIAS
GIG5,PNAS-107,S100A6BP,SIP
FUSION GENES

Other Information

Locus ID:

NCBI: 27101
MIM: 606186
HGNC: 30423
Ensembl: ENSG00000116161

Variants:

dbSNP: 27101
ClinVar: 27101
TCGA: ENSG00000116161
COSMIC: CACYBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116161ENST00000367679Q9HB71
ENSG00000116161ENST00000367679A0A024R904
ENSG00000116161ENST00000405362Q9HB71
ENSG00000116161ENST00000406752Q9HB71
ENSG00000116161ENST00000426793B2ZWH1
ENSG00000116161ENST00000613570Q9HB71

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
160856522005Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex.35
235438002013iTRAQ based quantitative proteomics approach validated the role of calcyclin binding protein (CacyBP) in promoting colorectal cancer metastasis.23
181719832007Calcyclin-binding protein inhibits proliferation, tumorigenicity, and invasion of gastric cancer.19
184433652008Expression of calcyclin-binding protein/Siah-1 interacting protein in normal and malignant human tissues: an immunohistochemical survey.18
212970762011Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.18
174001822007Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma.16
228748332012Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of β-catenin.11
124218092003Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP).9
128952922003Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells.9
205859482010CacyBP/SIP expression is involved in the clinical progression of breast cancer.9

Citation

Dessen P

CACYBP (calcyclin binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43780/cacybp-(calcyclin-binding-protein)