PSME1 (proteasome activator subunit 1)

Identity

HGNC

PSME1

LOCATION

14q12

LOCUSID

5720

ALIAS

HEL-S-129m,IFI5111,PA28A,PA28alpha,REGalpha

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 5720
MIM: 600654
HGNC: 9568
Ensembl: ENSG00000092010

Variants:

dbSNP: 5720
ClinVar: 5720
TCGA: ENSG00000092010
COSMIC: PSME1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000092010	ENST00000206451	Q06323
ENSG00000092010	ENST00000206451	A0A0K0K1L8
ENSG00000092010	ENST00000382708	Q06323
ENSG00000092010	ENST00000558112	H0YLU2
ENSG00000092010	ENST00000559123	H0YKK6
ENSG00000092010	ENST00000561435	Q06323

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Expression (GTEx)

0

100

200

300

400

500

600

700

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ABC transporter disorders	REACTOME	R-HSA-5619084
ABC-family proteins mediated transport	REACTOME	R-HSA-382556
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	REACTOME	R-HSA-176814
Activation of NF-kappaB in B cells	REACTOME	R-HSA-1169091
Adaptive Immune System	REACTOME	R-HSA-1280218
Antigen processing and presentation	KEGG	ko04612
Antigen processing and presentation	KEGG	hsa04612
Antigen processing-Cross presentation	REACTOME	R-HSA-1236975
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168
APC/C-mediated degradation of cell cycle proteins	REACTOME	R-HSA-174143

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22532226	2012	The C-terminal fragment of the immunoproteasome PA28S (Reg alpha) as an early diagnosis and tumor-relapse biomarker: evidence from mass spectrometry profiling.	10
23383295	2013	Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNβ in mouse pancreatic β-cells.	17
23383295	2013	Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNβ in mouse pancreatic β-cells.	17
23918357	2013	Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies.	14
23918357	2013	Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies.	14
26399368	2015	The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition.	29
26399368	2015	The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition.	29
26892607	2016	Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma.	12
26892607	2016	Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma.	12
26944190	2016	Circadian modulation of proteasome activity and accumulation of oxidized protein in human embryonic kidney HEK 293 cells and primary dermal fibroblasts.	10

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Citation

Dessen P

PSME1 (proteasome activator subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43788