USP22 (ubiquitin specific peptidase 22)

2007-02-01  

Identity

HGNC
USP22
LOCATION
17p11.2
LOCUSID
23326
ALIAS
USP3L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23326
MIM: 612116
HGNC: 12621
Ensembl: ENSG00000124422

Variants:

dbSNP: 23326
ClinVar: 23326
TCGA: ENSG00000124422
COSMIC: USP22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124422ENST00000261497Q9UPT9
ENSG00000124422ENST00000476111K7ERX6
ENSG00000124422ENST00000537526Q9UPT9
ENSG00000124422ENST00000579645J3QRV6
ENSG00000124422ENST00000582335J3QS30
ENSG00000124422ENST00000584538K7ESK0

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378983752024USP22-JMJD8 axis promotes Lenvatinib resistance in hepatocellular carcinoma.1
381762982024ADAM9 deubiquitination induced by USP22 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of trophoblast cells in preeclampsia.0
383475852024USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration.0
387843912024USP22 as a key regulator of glycolysis pathway in osteosarcoma: insights from bioinformatics and experimental approaches.0
378983752024USP22-JMJD8 axis promotes Lenvatinib resistance in hepatocellular carcinoma.1
381762982024ADAM9 deubiquitination induced by USP22 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of trophoblast cells in preeclampsia.0
383475852024USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration.0
387843912024USP22 as a key regulator of glycolysis pathway in osteosarcoma: insights from bioinformatics and experimental approaches.0
369066152023USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma.5
369066152023USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma.5
347434062022USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression.8
350398722022Long non‑coding RNA CTBP1‑AS2 upregulates USP22 to promote pancreatic carcinoma progression by sponging miR‑141‑3p.0
352032852022Upregulation of USP22 and ABCC1 during Sorafenib Treatment of Hepatocellular Carcinoma Contribute to Development of Resistance.5
354491572022USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma.36
359334022022USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING.9

Citation

Dessen P

USP22 (ubiquitin specific peptidase 22)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43796/usp22-(ubiquitin-specific-peptidase-22)