GCG (glucagon)

Identity

HGNC

GCG

LOCATION

2q24.2

LOCUSID

2641

ALIAS

GLP-1,GLP1,GLP2,GRPP

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 2641
MIM: 138030
HGNC: 4191
Ensembl: ENSG00000115263

Variants:

dbSNP: 2641
ClinVar: 2641
TCGA: ENSG00000115263
COSMIC: GCG

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115263	ENST00000375497	P01275
ENSG00000115263	ENST00000418842	P01275

Expression (GTEx)

0

50

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Class B/2 (Secretin family receptors)	REACTOME	R-HSA-373080
G alpha (q) signalling events	REACTOME	R-HSA-416476
G alpha (s) signalling events	REACTOME	R-HSA-418555
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Glucagon signaling in metabolic regulation	REACTOME	R-HSA-163359
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	REACTOME	R-HSA-381676
Glucagon-type ligand receptors	REACTOME	R-HSA-420092
GPCR downstream signaling	REACTOME	R-HSA-388396

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated	24624910
PA449061	clozapine	Chemical	ClinicalAnnotation	associated	24624910
PA450688	olanzapine	Chemical	ClinicalAnnotation	associated	24624910

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References

Pubmed ID	Year	Title	Citations
33940644	2023	SERUM GLP-2 is Increased in Association with Excess Gestational Weight Gain.	2
36539382	2023	Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion in humans: Characteristics and regulation.	4
36626940	2023	Glucagon 100 years. Important, but still enigmatic.	2
36639733	2023	Metabolic Messengers: glucagon.	7
36740132	2023	How gut hormones shape reward: A systematic review of the role of ghrelin and GLP-1 in human fMRI.	6
36744850	2023	Potential determinants of low circulating glucagon-like peptide 2 concentrations in Zambian children with non-responsive stunting.	1
36799940	2023	Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies.	8
38055342	2024	Crosstalk between glucagon-like peptide 1 and gut microbiota in metabolic diseases.	0
38055342	2024	Crosstalk between glucagon-like peptide 1 and gut microbiota in metabolic diseases.	0
38199777	2024	Association of GLP-1 secretion with parameters of glycemic control in women after gestational diabetes mellitus.	0

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Citation

Dessen P

GCG (glucagon)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43798/gcg-(glucagon)