GCG (glucagon)

2007-02-01  

Identity

HGNC
GCG
LOCATION
2q24.2
LOCUSID
2641
ALIAS
GLP-1,GLP1,GLP2,GRPP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2641
MIM: 138030
HGNC: 4191
Ensembl: ENSG00000115263

Variants:

dbSNP: 2641
ClinVar: 2641
TCGA: ENSG00000115263
COSMIC: GCG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115263ENST00000375497P01275
ENSG00000115263ENST00000418842P01275

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Insulin secretionKEGGhsa04911
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Synthesis, secretion, and deacylation of GhrelinREACTOMER-HSA-422085
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionREACTOMER-HSA-381676
Glucagon signaling in metabolic regulationREACTOMER-HSA-163359

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociated24624910
PA449061clozapineChemicalClinicalAnnotationassociated24624910
PA450688olanzapineChemicalClinicalAnnotationassociated24624910

References

Pubmed IDYearTitleCitations
380553422024Crosstalk between glucagon-like peptide 1 and gut microbiota in metabolic diseases.0
381997772024Association of GLP-1 secretion with parameters of glycemic control in women after gestational diabetes mellitus.0
386166462024Glucagon-Like Peptide 1: An Introduction and Possible Implications for Neuropsychiatry.0
387757252024Evaluating glucose-dependent insulinotropic polypeptide and glucagon as key regulators of insulin secretion in the pancreatic islet.0
380553422024Crosstalk between glucagon-like peptide 1 and gut microbiota in metabolic diseases.0
381997772024Association of GLP-1 secretion with parameters of glycemic control in women after gestational diabetes mellitus.0
386166462024Glucagon-Like Peptide 1: An Introduction and Possible Implications for Neuropsychiatry.0
387757252024Evaluating glucose-dependent insulinotropic polypeptide and glucagon as key regulators of insulin secretion in the pancreatic islet.0
339406442023SERUM GLP-2 is Increased in Association with Excess Gestational Weight Gain.2
365393822023Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion in humans: Characteristics and regulation.4
366269402023Glucagon 100 years. Important, but still enigmatic.2
366397332023Metabolic Messengers: glucagon.7
367401322023How gut hormones shape reward: A systematic review of the role of ghrelin and GLP-1 in human fMRI.6
367448502023Potential determinants of low circulating glucagon-like peptide 2 concentrations in Zambian children with non-responsive stunting.1
367999402023Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies.8

Citation

Dessen P

GCG (glucagon)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43798/gcg-(glucagon)