Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 81848
MIM: 607984
HGNC: 15533
Ensembl: ENSG00000187678
Variants:
dbSNP: 81848
ClinVar: 81848
TCGA: ENSG00000187678
COSMIC: SPRY4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000187678 | ENST00000344120 | A0A0C4DFS6 |
| ENSG00000187678 | ENST00000434127 | Q9C004 |
| ENSG00000187678 | ENST00000511815 | D6RB56 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32618153 | 2023 | Sprouty 4 suppresses glioblastoma invasion by inhibiting ERK phosphorylation and ETS-1-induced matrix metalloproteinase-9. | 2 |
| 36384366 | 2023 | Sprouty4 is epigenetically upregulated in human colorectal cancer. | 3 |
| 37042573 | 2023 | PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer progression via activating NF-κB signaling pathway. | 0 |
| 32618153 | 2023 | Sprouty 4 suppresses glioblastoma invasion by inhibiting ERK phosphorylation and ETS-1-induced matrix metalloproteinase-9. | 2 |
| 36384366 | 2023 | Sprouty4 is epigenetically upregulated in human colorectal cancer. | 3 |
| 37042573 | 2023 | PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer progression via activating NF-κB signaling pathway. | 0 |
| 36082406 | 2022 | SPRY4 promotes adipogenic differentiation of human mesenchymal stem cells through the MEK-ERK1/2 signaling pathway. | 1 |
| 36082406 | 2022 | SPRY4 promotes adipogenic differentiation of human mesenchymal stem cells through the MEK-ERK1/2 signaling pathway. | 1 |
| 32389901 | 2021 | Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism. | 5 |
| 33670044 | 2021 | A Sprouty4 Mutation Identified in Kallmann Syndrome Increases the Inhibitory Potency of the Protein towards FGF and Connected Processes. | 4 |
| 33757566 | 2021 | Long non-coding RNA SPRY4-IT1 as a promising indicator for three field lymph-node dissection of thoracic esophageal carcinoma. | 3 |
| 33879635 | 2021 | SPRY4 suppresses proliferation and induces apoptosis of colorectal cancer cells by repressing oncogene EZH2. | 5 |
| 33906393 | 2021 | Identification of SPRY4 as a Novel Candidate Susceptibility Gene for Familial Nonmedullary Thyroid Cancer. | 9 |
| 34048471 | 2021 | Sprouty4 negatively regulates ERK/MAPK signaling and the transition from in situ to invasive breast ductal carcinoma. | 1 |
| 34339801 | 2021 | Coupling HDAC4 with transcriptional factor MEF2D abrogates SPRY4-mediated suppression of ERK activation and elicits hepatocellular carcinoma drug resistance. | 8 |
Citation
Dessen P
SPRY4 (sprouty RTK signaling antagonist 4)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43800/spry4-(sprouty-rtk-signaling-antagonist-4)
