Identity
HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
ALS19,ALS20,HNRPA1,HNRPA1L3,IBMPFD3,UP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 20716340 | 2010 | Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues. | Boukakis G et al |
| 17898077 | 2007 | Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs. | Cammas A et al |
| 12799433 | 2003 | Specific interaction of heterogeneous nuclear ribonucleoprotein A1 with the -219T allelic form modulates APOE promoter activity. | Campillos M et al |
| 12716975 | 2003 | Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: a cause of vitamin D resistance. | Chen H et al |
| 29484423 | 2018 | High expression of hnRNPA1 promotes cell invasion by inducing EMT in gastric cancer. | Chen Y et al |
| 17950949 | 2008 | The alternative splicing factor hnRNP A1 is up-regulated during virus-infected epithelial cell differentiation and binds the human papillomavirus type 16 late regulatory element. | Cheunim T et al |
| 20010808 | 2010 | HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. | David CJ et al |
| 3072706 | 1988 | Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation. | Dreyfuss G et al |
| 24166503 | 2014 | microRNA-18a induces apoptosis in colon cancer cells via the autophagolysosomal degradation of oncogenic heterogeneous nuclear ribonucleoprotein A1. | Fujiya M et al |
| 27149842 | 2016 | Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma. | Giannakis M et al |
| 18391021 | 2008 | Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant. | Goina E et al |
| 17558416 | 2007 | The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. | Guil S et al |
| 20795951 | 2010 | Functional diversity of the hnRNPs: past, present and perspectives. | Han SP et al |
| 11313474 | 2001 | Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription. | Hay DC et al |
| 25338872 | 2015 | Loss of hnRNPA1 in ALS spinal cord motor neurons with TDP-43-positive inclusions. | Honda H et al |
| 12060656 | 2002 | Distinct sets of adjacent heterogeneous nuclear ribonucleoprotein (hnRNP) A1/A2 binding sites control 5' splice site selection in the hnRNP A1 mRNA precursor. | Hutchison S et al |
| 27066560 | 2015 | Isolated inclusion body myopathy caused by a multisystem proteinopathy-linked hnRNPA1 mutation. | Izumi R et al |
| 17289661 | 2007 | Molecular composition of IMP1 ribonucleoprotein granules. | Jønson L et al |
| 24065100 | 2013 | hnRNP A1: the Swiss army knife of gene expression. | Jean-Philippe J et al |
| 23455423 | 2013 | Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. | Kim HJ et al |
| 27984373 | 2017 | HNRNPA1, a Splicing Regulator, Is an Effective Target Protein for Cervical Cancer Detection: Comparison With Conventional Tumor Markers. | Kim YJ et al |
| 10972977 | 2000 | Heterogeneous nuclear ribonucleoproteins as regulators of gene expression through interactions with the human thymidine kinase promoter. | Lau JS et al |
| 27694260 | 2016 | Whole-exome sequencing identifies a missense mutation in hnRNPA1 in a family with flail arm ALS. | Liu Q et al |
| 26581508 | 2016 | Knockdown of HNRNPA1 inhibits lung adenocarcinoma cell proliferation through cell cycle arrest at G0/G1 phase. | Liu X et al |
| 26151392 | 2015 | CD44 alternative splicing and hnRNP A1 expression are associated with the metastasis of breast cancer. | Loh TJ et al |
| 22536116 | 2012 | Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs. | Martínez-Salas E et al |
| 15448691 | 2004 | Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise. | Mendell JT et al |
| 20639884 | 2010 | Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. | Michlewski G et al |
| 11585913 | 2001 | Distinct RNP complexes of shuttling hnRNP proteins with pre-mRNA and mRNA: candidate intermediates in formation and export of mRNA. | Mili S et al |
| 29872500 | 2018 | Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer. | Otsuka K et al |
| 1371331 | 1992 | Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. | Piñol-Roma S et al |
| 25324306 | 2014 | hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. | Roy R et al |
| 22922191 | 2012 | The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster. | Singh AK et al |
| 22132154 | 2011 | hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene. | Talukdar I et al |
| 23052036 | 2013 | Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells. | Teng Y et al |
| 15703818 | 2005 | Up-regulation of hnRNP A1 gene in sporadic human colorectal cancers. | Ushigome M et al |
| 15671034 | 2005 | Regulation of gamma-fibrinogen chain expression by heterogeneous nuclear ribonucleoprotein A1. | Xia H et al |
| 29367466 | 2018 | Mutations in Hnrnpa1 cause congenital heart defects. | Yu Z et al |
| 16603717 | 2006 | hnRNP A1 associates with telomere ends and stimulates telomerase activity. | Zhang QS et al |
| 22821376 | 2013 | Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma. | Zhou ZJ et al |
Other Information
Locus ID:
NCBI: 3178
MIM: 164017
HGNC: 5031
Ensembl: ENSG00000135486
Variants:
dbSNP: 3178
ClinVar: 3178
TCGA: ENSG00000135486
COSMIC: HNRNPA1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37897508 | 2024 | N6-methyladenosine modification of OIP5-AS1 promotes glycolysis, tumorigenesis, and metastasis of gastric cancer by inhibiting Trim21-mediated hnRNPA1 ubiquitination and degradation. | 2 |
| 38182429 | 2024 | A mutation in the low-complexity domain of splicing factor hnRNPA1 linked to amyotrophic lateral sclerosis disrupts distinct neuronal RNA splicing networks. | 0 |
| 38191621 | 2024 | hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS). | 2 |
| 38268030 | 2024 | MAGOH promotes gastric cancer progression via hnRNPA1 expression inhibition-mediated RONΔ160/PI3K/AKT signaling pathway activation. | 0 |
| 38685451 | 2024 | circLIFR-007 reduces liver metastasis via promoting hnRNPA1 nuclear export and YAP phosphorylation in breast cancer. | 1 |
| 38867190 | 2024 | Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing. | 0 |
| 37897508 | 2024 | N6-methyladenosine modification of OIP5-AS1 promotes glycolysis, tumorigenesis, and metastasis of gastric cancer by inhibiting Trim21-mediated hnRNPA1 ubiquitination and degradation. | 2 |
| 38182429 | 2024 | A mutation in the low-complexity domain of splicing factor hnRNPA1 linked to amyotrophic lateral sclerosis disrupts distinct neuronal RNA splicing networks. | 0 |
| 38191621 | 2024 | hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS). | 2 |
| 38268030 | 2024 | MAGOH promotes gastric cancer progression via hnRNPA1 expression inhibition-mediated RONΔ160/PI3K/AKT signaling pathway activation. | 0 |
| 38685451 | 2024 | circLIFR-007 reduces liver metastasis via promoting hnRNPA1 nuclear export and YAP phosphorylation in breast cancer. | 1 |
| 38867190 | 2024 | Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing. | 0 |
| 36460805 | 2023 | A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA. | 4 |
| 37525910 | 2023 | HnRNP A1 Suppresses the Odontogenic Differentiation and the Inclusion of RUNX2 Exon 5 of Dental Mesenchymal Cells. | 0 |
| 37717939 | 2023 | The mechanism of UP1 binding and unfolding of human telomeric DNA G-quadruplex. | 0 |
Citation
Dessen P
HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43803/hnrnpa1
