KCNA3 (potassium voltage-gated channel subfamily A member 3)

2007-02-01  

Identity

HGNC
LOCATION
1p13.3
LOCUSID
ALIAS
HGK5,HLK3,HPCN3,HUKIII,KV1.3,MK3,PCN3

Other Information

Locus ID:

NCBI: 3738
MIM: 176263
HGNC: 6221
Ensembl: ENSG00000177272

Variants:

dbSNP: 3738
ClinVar: 3738
TCGA: ENSG00000177272
COSMIC: KCNA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177272ENST00000369769P22001

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Voltage gated Potassium channelsREACTOMER-HSA-1296072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170885642006Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.174
160437142005The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain.70
156321412005A novel potassium channel in lymphocyte mitochondria.49
188183042008Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes.46
178783532007Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes.36
147450402004Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells.35
191046612008Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes.33
210876022011Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo.30
126047822003Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes.29
126321872003Cholesterol modifies the gating of Kv1.3 in human T lymphocytes.29

Citation

Dessen P

KCNA3 (potassium voltage-gated channel subfamily A member 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43811/kcna3-(potassium-voltage-gated-channel-subfamily-a-member-3)