EIF5A (eukaryotic translation initiation factor 5A)

2007-02-01  

Identity

HGNC
EIF5A
LOCATION
17p13.1
LOCUSID
1984
ALIAS
EIF-5A,EIF5A1,eIF-4D,eIF5AI
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1984
MIM: 600187
HGNC: 3300
Ensembl: ENSG00000132507

Variants:

dbSNP: 1984
ClinVar: 1984
TCGA: ENSG00000132507
COSMIC: EIF5A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132507ENST00000336452P63241
ENSG00000132507ENST00000336458P63241
ENSG00000132507ENST00000416016P63241
ENSG00000132507ENST00000419711P63241
ENSG00000132507ENST00000571955P63241
ENSG00000132507ENST00000572815I3L504
ENSG00000132507ENST00000573542P63241
ENSG00000132507ENST00000573714I3L397
ENSG00000132507ENST00000576930P63241

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activationREACTOMER-HSA-163841
Hypusine synthesis from eIF5A-lysineREACTOMER-HSA-204626

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386543322024AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.2
388626932024Construction of a nomogram for predicting HNSCC distant metastasis and identification of EIF5A as a hub gene.0
386543322024AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.2
388626932024Construction of a nomogram for predicting HNSCC distant metastasis and identification of EIF5A as a hub gene.0
367667512023Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress.1
368938942023Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.7
369732442023Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders.3
370470392023Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability.1
371377902023High levels of hypusinated eIF5A in leiomyoma and leiomyosarcoma pathologies: a possible novel therapeutic target.2
372196652023Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.2
373337702023Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.1
376530212023Targeted inhibition of eIF5A(hpu) suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.5
377430082023Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.1
367667512023Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress.1
368938942023Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.7

Citation

Dessen P

EIF5A (eukaryotic translation initiation factor 5A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43812