EIF5A (eukaryotic translation initiation factor 5A)

2007-02-01 Affiliation

Identity

HGNC

EIF5A

LOCATION

17p13.1

LOCUSID

1984

ALIAS

EIF-5A,EIF5A1,eIF-4D,eIF5AI

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1984
MIM: 600187
HGNC: 3300
Ensembl: ENSG00000132507

Variants:

dbSNP: 1984
ClinVar: 1984
TCGA: ENSG00000132507
COSMIC: EIF5A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000132507	ENST00000336452	P63241
ENSG00000132507	ENST00000336458	P63241
ENSG00000132507	ENST00000416016	P63241
ENSG00000132507	ENST00000419711	P63241
ENSG00000132507	ENST00000571955	P63241
ENSG00000132507	ENST00000572815	I3L504
ENSG00000132507	ENST00000573542	P63241
ENSG00000132507	ENST00000573714	I3L397
ENSG00000132507	ENST00000576930	P63241

Expression (GTEx)

100

200

300

400

500

600

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activation	REACTOME	R-HSA-163841
Hypusine synthesis from eIF5A-lysine	REACTOME	R-HSA-204626

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19825182	2009	Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A.	47
15371445	2004	A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis.	44
11161802	2001	Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.	40
20830705	2011	Overexpression of eIF5A-2 is an adverse prognostic marker of survival in stage I non-small cell lung cancer patients.	39
17008552	2007	Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach.	38
25979826	2015	The translation factor eIF5A and human cancer.	38
17187778	2007	Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling.	35
25261239	2014	A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer.	34
21360055	2011	Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3.	29
16519677	2006	Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells.	28

Citation

Dessen P

EIF5A (eukaryotic translation initiation factor 5A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43812/eif5a-(eukaryotic-translation-initiation-factor-5a)