ANGPTL4 (angiopoietin like 4)

2007-02-01  

Identity

HGNC
ANGPTL4
LOCATION
19p13.2
LOCUSID
51129
ALIAS
ARP4,FIAF,HARP,HFARP,NL2,PGAR,TGQTL,UNQ171,pp1158
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51129
MIM: 605910
HGNC: 16039
Ensembl: ENSG00000167772

Variants:

dbSNP: 51129
ClinVar: 51129
TCGA: ENSG00000167772
COSMIC: ANGPTL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167772ENST00000301455Q9BY76
ENSG00000167772ENST00000393962Q9BY76
ENSG00000167772ENST00000593998Q9BY76
ENSG00000167772ENST00000594875M0R2X8
ENSG00000167772ENST00000595079M0R369
ENSG00000167772ENST00000599192M0R3A2
ENSG00000167772ENST00000601770M0R0N8
ENSG00000167772ENST00000601886M0QZ51

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
PPAR signaling pathwayKEGGhsa03320
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
Chylomicron-mediated lipid transportREACTOMER-HSA-174800
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190609062009Common variants at 30 loci contribute to polygenic dyslipidemia.552
183949902008TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4.345
173228812007Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.229
160816402005Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism.144
218604102012HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.130
269345672016Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.126
269337532016Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.108
151900762004The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment.96
127070352003Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma.89
127070352003Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma.89

Citation

Dessen P

ANGPTL4 (angiopoietin like 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43819/angptl4-(angiopoietin-like-4)