Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4548
MIM: 156570
HGNC: 7468
Ensembl: ENSG00000116984
Variants:
dbSNP: 4548
ClinVar: 4548
TCGA: ENSG00000116984
COSMIC: MTR
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443297 | Agranulocytosis | Disease | ClinicalAnnotation | associated | PD | 24712521 | |
| PA443553 | Brain Diseases | Disease | VariantAnnotation | associated | PD | 17855192 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PD | 19159907, 21605004, 29662106 | |
| PA447288 | Essential hypertension | Disease | ClinicalAnnotation | associated | PD | 15148588 | |
| PA448561 | benazepril | Chemical | ClinicalAnnotation | associated | PD | 15148588 | |
| PA448803 | carboplatin | Chemical | ClinicalAnnotation | associated | PD | 19159907, 21605004, 29662106 | |
| PA449014 | cisplatin | Chemical | ClinicalAnnotation | associated | PD | 19159907, 21605004, 29662106 | |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 15797993, 16013960, 17611986, 17855192, 18322994, 19159907, 22838948, 24712521, 27217051, 27676277 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38325832 | 2024 | Genetic Association between the Risk of Dental Caries and MTR Gene Polymorphism in Chinese Children. | 0 |
| 38325832 | 2024 | Genetic Association between the Risk of Dental Caries and MTR Gene Polymorphism in Chinese Children. | 0 |
| 37249073 | 2023 | Association of MTR A2756G and MTRR A66G Polymorphisms With Male Infertility: An Updated Meta-Analysis. | 0 |
| 37296303 | 2023 | Association of MTR gene polymorphisms with the occurrence of non-syndromic congenital heart disease: a case-control study. | 1 |
| 37531512 | 2023 | Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries. | 0 |
| 37628752 | 2023 | Common Variants in One-Carbon Metabolism Genes (MTHFR, MTR, MTHFD1) and Depression in Gynecologic Cancers. | 0 |
| 37249073 | 2023 | Association of MTR A2756G and MTRR A66G Polymorphisms With Male Infertility: An Updated Meta-Analysis. | 0 |
| 37296303 | 2023 | Association of MTR gene polymorphisms with the occurrence of non-syndromic congenital heart disease: a case-control study. | 1 |
| 37531512 | 2023 | Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries. | 0 |
| 37628752 | 2023 | Common Variants in One-Carbon Metabolism Genes (MTHFR, MTR, MTHFD1) and Depression in Gynecologic Cancers. | 0 |
| 33345688 | 2022 | MTR-G is a high-risk allele for lower-extremity arteriosclerotic occlusion. | 1 |
| 35332781 | 2022 | Folate metabolism abnormalities in infertile patients with endometriosis. | 1 |
| 35468734 | 2022 | "Association of MTHFR and MS/MTR gene polymorphisms with congenital heart defects in North Indian population (Jammu and Kashmir): a case-control study encompassing meta-analysis and trial sequential analysis". | 1 |
| 35715601 | 2022 | Investigation of the relationship between MTRR A66G, MTR A2756G gene variations and cell anomalies in early diagnosis and progression of bladder cancer. | 0 |
| 35802641 | 2022 | Association between MTR A2756G polymorphism and susceptibility to congenital heart disease: A meta-analysis. | 0 |
Citation
Dessen P
MTR (5-methyltetrahydrofolate-homocysteine methyltransferase)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43820/mtr-(5-methyltetrahydrofolate-homocysteine-methyltransferase)
