MED15 (mediator complex subunit 15)

2007-02-01  

Identity

HGNC
MED15
LOCATION
22q11.21
LOCUSID
51586
ALIAS
ARC105,CAG7A,CTG7A,PCQAP,TIG-1,TIG1,TNRC7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51586
MIM: 607372
HGNC: 14248
Ensembl: ENSG00000099917

Variants:

dbSNP: 51586
ClinVar: 51586
TCGA: ENSG00000099917
COSMIC: MED15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099917ENST00000263205Q96RN5
ENSG00000099917ENST00000292733Q96RN5
ENSG00000099917ENST00000382974Q96RN5
ENSG00000099917ENST00000406969G3V1P5
ENSG00000099917ENST00000414658C9J1I1
ENSG00000099917ENST00000420849F8WCS1
ENSG00000099917ENST00000423862H7C308
ENSG00000099917ENST00000424287C9JCQ3
ENSG00000099917ENST00000428629C9JWK5
ENSG00000099917ENST00000432052C9JLN7
ENSG00000099917ENST00000433831F2Z2B7
ENSG00000099917ENST00000438962C9JEM1
ENSG00000099917ENST00000441501F8WEJ4
ENSG00000099917ENST00000444094F8WDM6
ENSG00000099917ENST00000445189C9JGN2
ENSG00000099917ENST00000445987C9JZV5
ENSG00000099917ENST00000451058C9JM58
ENSG00000099917ENST00000457322C9JJ12

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369970322023Cystic MED15::TFE3 translocation renal cell carcinoma: histologic mimicker of multilocular cystic renal neoplasm of low malignant potential with review of the literature.1
369970322023Cystic MED15::TFE3 translocation renal cell carcinoma: histologic mimicker of multilocular cystic renal neoplasm of low malignant potential with review of the literature.1
337720812021MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation.6
339043982021Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator.55
337720812021MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation.6
339043982021Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator.55
324399762020MED15, transforming growth factor beta 1 (TGF-β1), FcγRIII (CD16), and HNK-1 (CD57) are prognostic biomarkers of oral squamous cell carcinoma.3
324399762020MED15, transforming growth factor beta 1 (TGF-β1), FcγRIII (CD16), and HNK-1 (CD57) are prognostic biomarkers of oral squamous cell carcinoma.3
318281082019A Rare Partner of TFE3 in the Xp11 Translocation Renal Cell Carcinoma: Clinicopathological Analyses and Detection of MED15-TFE3 Fusion.3
318281082019A Rare Partner of TFE3 in the Xp11 Translocation Renal Cell Carcinoma: Clinicopathological Analyses and Detection of MED15-TFE3 Fusion.3
294006612018The Mediator complex subunit MED15, a promoter of tumour progression and metastatic spread in renal cell carcinoma.7
294006612018The Mediator complex subunit MED15, a promoter of tumour progression and metastatic spread in renal cell carcinoma.7
279747042017MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling.11
279747042017MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling.11
257916372015Clinical and molecular implications of MED15 in head and neck squamous cell carcinoma.12

Citation

Dessen P

MED15 (mediator complex subunit 15)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43823