Identity
HGNC
LOCATION
5q11.2
LOCUSID
ALIAS
ACRDYS2,DPDE3,HSPDE4D,PDE43,PDE4DN2,STRK1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5144
MIM: 600129
HGNC: 8783
Ensembl: ENSG00000113448
Variants:
dbSNP: 5144
ClinVar: 5144
TCGA: ENSG00000113448
COSMIC: PDE4D
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA151249535 | diuretics | Chemical | ClinicalAnnotation | associated | PD | 23778321 | |
| PA445086 | Nephrosclerosis | Disease | ClinicalAnnotation | associated | PD | 23778321 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | ||
| PA451201 | quetiapine | Chemical | ClinicalAnnotation | associated | PD | ||
| PA59 | ARRB1 | Gene | Pathway | associated | |||
| PA60 | ARRB2 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38172709 | 2024 | PDE4D single nucleotide polymorphism rs918592 is associated with ischemic Stroke risk in Chinese populations: a meta-analysis. | 0 |
| 38319157 | 2024 | GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines. | 0 |
| 38172709 | 2024 | PDE4D single nucleotide polymorphism rs918592 is associated with ischemic Stroke risk in Chinese populations: a meta-analysis. | 0 |
| 38319157 | 2024 | GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines. | 0 |
| 36862303 | 2023 | Phosphodiesterase 4 D (PDE4D) gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis. | 0 |
| 37427586 | 2023 | Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth. | 4 |
| 37549468 | 2023 | PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children. | 0 |
| 37994145 | 2023 | [Research progress on genetic variants of PDE4D and susceptibility to stroke in Chinese population]. | 0 |
| 38272484 | 2023 | Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study. | 0 |
| 36862303 | 2023 | Phosphodiesterase 4 D (PDE4D) gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis. | 0 |
| 37427586 | 2023 | Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth. | 4 |
| 37549468 | 2023 | PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children. | 0 |
| 37994145 | 2023 | [Research progress on genetic variants of PDE4D and susceptibility to stroke in Chinese population]. | 0 |
| 38272484 | 2023 | Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study. | 0 |
| 35420310 | 2022 | Association of plaque enhancement on vessel wall MRI and the phosphodiesterase 4D variant with stroke recurrence in patients with symptomatic intracranial atherosclerosis. | 3 |
Citation
Dessen P
PDE4D (phosphodiesterase 4D)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43832/pde4d-(phosphodiesterase-4d)
