PTGFR (prostaglandin F receptor)

2007-02-01  

Identity

HGNC
PTGFR
LOCATION
1p31.1
LOCUSID
5737
ALIAS
FP

Other Information

Locus ID:

NCBI: 5737
MIM: 600563
HGNC: 9600
Ensembl: ENSG00000122420

Variants:

dbSNP: 5737
ClinVar: 5737
TCGA: ENSG00000122420
COSMIC: PTGFR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122420ENST00000370756P43088
ENSG00000122420ENST00000370757P43088
ENSG00000122420ENST00000370758P43088
ENSG00000122420ENST00000497923F2Z2Z6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Eicosanoid ligand-binding receptorsREACTOMER-HSA-391903
Prostanoid ligand receptorsREACTOMER-HSA-391908
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164774763latanoprostChemicalClinicalAnnotationassociatedPD17467803, 25339146, 27336732
PA444282Glaucoma, Open-AngleDiseaseClinicalAnnotationassociatedPD17467803, 25339146, 27336732

References

Pubmed IDYearTitleCitations
371608912023Ligand-induced activation and G protein coupling of prostaglandin F(2α) receptor.4
371608912023Ligand-induced activation and G protein coupling of prostaglandin F(2α) receptor.4
341749232021Replicative verification of susceptibility genes previously identified from families with segregating developmental dysplasia of the hip.1
341749232021Replicative verification of susceptibility genes previously identified from families with segregating developmental dysplasia of the hip.1
297735552018Prostaglandin F(2α) Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.25
297735552018Prostaglandin F(2α) Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.25
278620862017Correlations of AFAP1, GMDS and PTGFR gene polymorphisms with intra-ocular pressure response to latanoprost in patients with primary open-angle glaucoma.8
285840542017Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors.12
278620862017Correlations of AFAP1, GMDS and PTGFR gene polymorphisms with intra-ocular pressure response to latanoprost in patients with primary open-angle glaucoma.8
285840542017Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors.12
253391462015Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients.8
255123742015Angiotensin II type I and prostaglandin F2α receptors cooperatively modulate signaling in vascular smooth muscle cells.29
257043192015Association between SNPs of Metalloproteinases and Prostaglandin F2α Receptor Genes and Latanoprost Response in Open-Angle Glaucoma.17
259775692015Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F2α Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population.7
26170067201511β-Prostaglandin F2α, a bioactive metabolite catalyzed by AKR1C3, stimulates prostaglandin F receptor and induces slug expression in breast cancer.12

Citation

Dessen P

PTGFR (prostaglandin F receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43835/ptgfr-(prostaglandin-f-receptor)