HPGD (15-hydroxyprostaglandin dehydrogenase)

2007-02-01  

Identity

HGNC
HPGD
LOCATION
4q34.1
LOCUSID
3248
ALIAS
15-PGDH,PGDH,PGDH1,PHOAR1,SDR36C1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3248
MIM: 601688
HGNC: 5154
Ensembl: ENSG00000164120

Variants:

dbSNP: 3248
ClinVar: 3248
TCGA: ENSG00000164120
COSMIC: HPGD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164120ENST00000296521P15428
ENSG00000164120ENST00000296522P15428
ENSG00000164120ENST00000422112P15428
ENSG00000164120ENST00000504433E9PBZ2
ENSG00000164120ENST00000506910D6RA83
ENSG00000164120ENST00000508330E9PD69
ENSG00000164120ENST00000510835D6RHF8
ENSG00000164120ENST00000510901P15428
ENSG00000164120ENST00000514584D6RA66
ENSG00000164120ENST00000541923P15428
ENSG00000164120ENST00000542498P15428

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)REACTOMER-HSA-2162123
Synthesis of Lipoxins (LX)REACTOMER-HSA-2142700

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375916932023Reclassification of the HPGD p.Ala13Glu variant causing primary hypertrophic osteoarthropathy.0
375916932023Reclassification of the HPGD p.Ala13Glu variant causing primary hypertrophic osteoarthropathy.0
348801252022Epigenetic Silencing of 15-Hydroxyprostaglandin Dehydrogenase by Histone Methyltransferase EHMT2/G9a in Cholangiocarcinoma.4
358134632022Clinical and biochemical characteristics of 12 Chinese primary hypertrophic osteoarthropathy patients with HPGD mutations.2
348801252022Epigenetic Silencing of 15-Hydroxyprostaglandin Dehydrogenase by Histone Methyltransferase EHMT2/G9a in Cholangiocarcinoma.4
358134632022Clinical and biochemical characteristics of 12 Chinese primary hypertrophic osteoarthropathy patients with HPGD mutations.2
333036832021Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength.67
333036832021Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength.67
321004502020Association between COX-2 and 15-PGDH polymorphisms and SLE susceptibility.7
321004502020Association between COX-2 and 15-PGDH polymorphisms and SLE susceptibility.7
309319802019miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.10
310279982019Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.39
316467992019Single nucleotide polymorphism rs2555639 in 15-PGDH and colorectal cancer metastasis.1
309319802019miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.10
310279982019Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.39

Citation

Dessen P

HPGD (15-hydroxyprostaglandin dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43840/hpgd-(15-hydroxyprostaglandin-dehydrogenase)