TBXA2R (thromboxane A2 receptor)

2007-02-01 Affiliation

Identity

HGNC

TBXA2R

LOCATION

19p13.3

LOCUSID

6915

ALIAS

BDPLT13,TXA2-R

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6915
MIM: 188070
HGNC: 11608
Ensembl: ENSG00000006638

Variants:

dbSNP: 6915
ClinVar: 6915
TCGA: ENSG00000006638
COSMIC: TBXA2R

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000006638	ENST00000375190	P21731
ENSG00000006638	ENST00000411851	P21731
ENSG00000006638	ENST00000589966	K7ER80

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Platelet activation	KEGG	hsa04611
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Signal amplification	REACTOME	R-HSA-392518
Thromboxane signalling through TP receptor	REACTOME	R-HSA-428930
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Eicosanoid ligand-binding receptors	REACTOME	R-HSA-391903
Prostanoid ligand receptors	REACTOME	R-HSA-391908
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
G alpha (12/13) signalling events	REACTOME	R-HSA-416482
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA174	GNAQ	Gene	Pathway	associated		20938371
PA176	GNB3	Gene	Pathway	associated		20938371
PA28764	GNA11	Gene	Pathway	associated		20938371
PA28765	GNA12	Gene	Pathway	associated		20938371
PA28766	GNA13	Gene	Pathway	associated		20938371
PA28768	GNA15	Gene	Pathway	associated		20938371
PA443450	Asthma	Disease	ClinicalAnnotation	associated	PD	15898979
PA443890	Diabetes Mellitus, Type 2	Disease	ClinicalAnnotation	associated	PD
PA448497	aspirin	Chemical	ClinicalAnnotation	associated	PD	15898979, 17245331, 23688183

References

Pubmed ID	Year	Title	Citations
36936944	2023	In silico analysis of single nucleotide polymorphism (rs34377097) of TBXA2R gene and pollen induced bronchial asthma susceptibility in West Bengal population, India.	2
36936944	2023	In silico analysis of single nucleotide polymorphism (rs34377097) of TBXA2R gene and pollen induced bronchial asthma susceptibility in West Bengal population, India.	2
35525325	2022	Thromboxane A(2) receptor activation via G(α13)-RhoA/C-ROCK-LIMK2-dependent signal transduction inhibits angiogenic sprouting of human endothelial cells.	1
35525325	2022	Thromboxane A(2) receptor activation via G(α13)-RhoA/C-ROCK-LIMK2-dependent signal transduction inhibits angiogenic sprouting of human endothelial cells.	1
31858582	2020	Signal transducer and activator of transcription 3 (STAT3) phosphorylation regulates thromboxane A(2) receptor activity in human platelets.	1
32810763	2020	The association between thromboxane A(2) receptor gene polymorphisms and the risk of cerebral infarction.	0
32971583	2020	Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis.	4
31858582	2020	Signal transducer and activator of transcription 3 (STAT3) phosphorylation regulates thromboxane A(2) receptor activity in human platelets.	1
32810763	2020	The association between thromboxane A(2) receptor gene polymorphisms and the risk of cerebral infarction.	0
32971583	2020	Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis.	4
30914039	2019	The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke.	4
31271729	2019	Differential expression of the TPα and TPβ isoforms of the human T Prostanoid receptor during chronic inflammation of the prostate: Role for FOXP1 in the transcriptional regulation of TPβ during monocyte-macrophage differentiation.	2
30914039	2019	The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke.	4
31271729	2019	Differential expression of the TPα and TPβ isoforms of the human T Prostanoid receptor during chronic inflammation of the prostate: Role for FOXP1 in the transcriptional regulation of TPβ during monocyte-macrophage differentiation.	2
28709878	2018	Differential TBXA2 receptor transcript stability is dependent on the C924T polymorphism.	2

Citation

Dessen P

TBXA2R (thromboxane A2 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43842