NOX1 (NADPH oxidase 1)

2007-02-01  

Identity

HGNC
NOX1
LOCATION
Xq22.1
LOCUSID
27035
ALIAS
GP91-2,MOX1,NOH-1,NOH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27035
MIM: 300225
HGNC: 7889
Ensembl: ENSG00000007952

Variants:

dbSNP: 27035
ClinVar: 27035
TCGA: ENSG00000007952
COSMIC: NOX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007952ENST00000217885Q9Y5S8
ENSG00000007952ENST00000372960A6NGA6
ENSG00000007952ENST00000372964Q5H9D4
ENSG00000007952ENST00000372966Q9Y5S8
ENSG00000007952ENST00000427768H0Y581

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Leukocyte transendothelial migrationKEGGko04670
Leukocyte transendothelial migrationKEGGhsa04670
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
HIF-1 signaling pathwayKEGGhsa04066
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate NADPH OxidasesREACTOMER-HSA-5668599
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

References

Pubmed IDYearTitleCitations
216292952011Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets.285
146709342004Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells.220
153220912004Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase.181
235646682013NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis.121
232419622013Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.106
166360672006Nox1-dependent reactive oxygen generation is regulated by Rac1.97
153897902005Increased Nox1 and hydrogen peroxide in prostate cancer.94
167789892006A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites.91
165079942006Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases.79
250661922014Endothelial NADPH oxidases: which NOX to target in vascular disease?78

Citation

Dessen P

NOX1 (NADPH oxidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43856/nox1-(nadph-oxidase-1)