B3GNT8 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8)

2007-02-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
B3GALT7,BGALT15,beta3Gn-T8

Other Information

Locus ID:

NCBI: 374907
MIM: 615357
HGNC: 24139
Ensembl: ENSG00000177191

Variants:

dbSNP: 374907
ClinVar: 374907
TCGA: ENSG00000177191
COSMIC: B3GNT8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177191ENST00000321702Q7Z7M8

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188269412008Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells.15
245731032014β3GnT8 regulates the metastatic potential of colorectal carcinoma cells by altering the glycosylation of CD147.8
249700532014β3GnT8 plays an important role in CD147 signal transduction as an upstream modulator of MMP production in tumor cells.7
209635022011Regulation of MMP-2 expression and activity by β-1,3-N-acetylglucosaminyltransferase-8 in AGS gastric cancer cells.5
293934912018β3GnT8 regulates oxaliplatin resistance by altering integrin β1 glycosylation in colon cancer cells.1
154864592004Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family.0
156206932005A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer.0
214685982011Down-regulation of β-1,3-N-acetylglucosaminyltransferase-8 by siRNA inhibits the growth of human gastric cancer.0
229011752012β3GnT8 regulates laryngeal carcinoma cell proliferation via targeting MMPs/TIMPs and TGF-β1.0
247150952014High expression of β3GnT8 is associated with the metastatic potential of human glioma.0

Citation

Dessen P

B3GNT8 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43857/b3gnt8-(udp-glcnac-betagal-beta-1-3-n-acetylglucosaminyltransferase-8)