FYCO1 (FYVE and coiled-coil domain autophagy adaptor 1)

2007-02-01  

Identity

HGNC
FYCO1
LOCATION
3p21.31
LOCUSID
79443
ALIAS
CATC2,CTRCT18,RUFY3,ZFYVE7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79443
MIM: 607182
HGNC: 14673
Ensembl: ENSG00000163820

Variants:

dbSNP: 79443
ClinVar: 79443
TCGA: ENSG00000163820
COSMIC: FYCO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163820ENST00000296137Q9BQS8
ENSG00000163820ENST00000433878H7BZ74
ENSG00000163820ENST00000438446C9J2W6
ENSG00000163820ENST00000535325Q9BQS8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
201009112010FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport.193
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
216360662011Mutations in FYCO1 cause autosomal-recessive congenital cataracts.59
264682872015FYCO1 Contains a C-terminally Extended, LC3A/B-preferring LC3-interacting Region (LIR) Motif Required for Efficient Maturation of Autophagosomes during Basal Autophagy.31
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
280090832017Proteomics of rimmed vacuoles define new risk allele in inclusion body myositis.12
272462472016Structural basis of FYCO1 and MAP1LC3A interaction reveals a novel binding mode for Atg8-family proteins.11
118964562002The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3.10
291964752017FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation.4

Citation

Dessen P

FYCO1 (FYVE and coiled-coil domain autophagy adaptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43868/fyco1-(fyve-and-coiled-coil-domain-autophagy-adaptor-1)