IL4I1 (interleukin 4 induced 1)

2007-02-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
FIG1,LAAO,LAO,hIL4I1
FUSION GENES

Other Information

Locus ID:

NCBI: 259307
MIM: 609742
HGNC: 19094
Ensembl: ENSG00000104951

Variants:

dbSNP: 259307
ClinVar: 259307
TCGA: ENSG00000104951
COSMIC: IL4I1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104951ENST00000341114Q96RQ9
ENSG00000104951ENST00000391826Q96RQ9
ENSG00000104951ENST00000593956M0QYW8
ENSG00000104951ENST00000595948Q96RQ9
ENSG00000104951ENST00000596011M0R2S9
ENSG00000104951ENST00000596022M0R1L1
ENSG00000104951ENST00000597295M0QYH9
ENSG00000104951ENST00000601717M0QXY7

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Valine, leucine and isoleucine degradationKEGGko00280
Tyrosine metabolismKEGGko00350
Phenylalanine metabolismKEGGko00360
Tryptophan metabolismKEGGko00380
Phenylalanine, tyrosine and tryptophan biosynthesisKEGGko00400
Valine, leucine and isoleucine degradationKEGGhsa00280
Tyrosine metabolismKEGGhsa00350
Phenylalanine metabolismKEGGhsa00360
Tryptophan metabolismKEGGhsa00380
Phenylalanine, tyrosine and tryptophan biosynthesisKEGGhsa00400
Alanine, aspartate and glutamate metabolismKEGGko00250
Alanine, aspartate and glutamate metabolismKEGGhsa00250
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Tyrosine degradation, tyrosine => homogentisateKEGGM00044
Tyrosine degradation, tyrosine => homogentisateKEGGhsa_M00044
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Phenylalanine and tyrosine catabolismREACTOMER-HSA-71182
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
360569352023IL4I1 enhances PD-L1 expression through JAK/STAT signaling pathway in lung adenocarcinoma.10
368345762023Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon Receptor.4
369130962023Knockdown of IL4I1 Improved High Glucose-evoked Insulin Resistance in HepG2 Cells by Alleviating Inflammation and Lipotoxicity Through AHR Activation.1
371967682023IL4i1 and IDO1: Oxidases that control a tryptophan metabolic nexus in cancer.5
382500742023IL4I1 in M2-like macrophage promotes glioma progression and is a promising target for immunotherapy.1
360569352023IL4I1 enhances PD-L1 expression through JAK/STAT signaling pathway in lung adenocarcinoma.10
368345762023Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon Receptor.4
369130962023Knockdown of IL4I1 Improved High Glucose-evoked Insulin Resistance in HepG2 Cells by Alleviating Inflammation and Lipotoxicity Through AHR Activation.1
371967682023IL4i1 and IDO1: Oxidases that control a tryptophan metabolic nexus in cancer.5
382500742023IL4I1 in M2-like macrophage promotes glioma progression and is a promising target for immunotherapy.1
359525162022Pan-cancer analysis combined with experimental validation revealed IL4I1 as an immunological and prognostic biomarker.3
361319182022IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike.1
359525162022Pan-cancer analysis combined with experimental validation revealed IL4I1 as an immunological and prognostic biomarker.3
361319182022IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike.1
336923372021IL4I1-driven AHR signature: a new avenue for cancer therapy.11

Citation

Dessen P

IL4I1 (interleukin 4 induced 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43872/il4i1-(interleukin-4-induced-1)