CARM1 (coactivator associated arginine methyltransferase 1)

2007-02-01

Identity

HGNC

CARM1

LOCATION

19p13.2

LOCUSID

10498

ALIAS

PRMT4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10498
MIM: 603934
HGNC: 23393
Ensembl: ENSG00000142453

Variants:

dbSNP: 10498
ClinVar: 10498
TCGA: ENSG00000142453
COSMIC: CARM1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000142453	ENST00000327064	Q86X55
ENSG00000142453	ENST00000344150	Q86X55
ENSG00000142453	ENST00000586221	K7EQA8
ENSG00000142453	ENST00000586298	K7EQB9
ENSG00000142453	ENST00000588947	K7EK20
ENSG00000142453	ENST00000589693	K7ERM3
ENSG00000142453	ENST00000590039	K7EIQ8
ENSG00000142453	ENST00000590699	K7EPK1

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Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Activation of gene expression by SREBF (SREBP)	REACTOME	R-HSA-2426168
BMAL1:CLOCK,NPAS2 activates circadian gene expression	REACTOME	R-HSA-1368108
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
Chromatin organization	REACTOME	R-HSA-4839726
Circadian Clock	REACTOME	R-HSA-400253
Developmental Biology	REACTOME	R-HSA-1266738
Endocrine resistance	KEGG	ko01522
Endocrine resistance	KEGG	hsa01522
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Gene Expression	REACTOME	R-HSA-74160

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35354645	2023	Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis.	4
35354645	2023	Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis.	4
37196782	2023	Unraveling the complexity of histone-arginine methyltransferase CARM1 in cancer: From underlying mechanisms to targeted therapeutics.	0
37216643	2023	PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ.	1
37365888	2023	Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity.	0
37477799	2023	Inhibition of CARM1 suppresses proliferation of multiple myeloma cells through activation of p53 signaling pathway.	0
37995178	2023	BACH1 regulates the differentiation of vascular smooth muscle cells from human embryonic stem cells via CARM1-mediated methylation of H3R17.	0
38223978	2024	Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1.	0
38223978	2024	Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1.	0
38649367	2024	Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity.	0

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Citation

Dessen P

CARM1 (coactivator associated arginine methyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43874