CARM1 (coactivator associated arginine methyltransferase 1)

2007-02-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
PRMT4
FUSION GENES

Other Information

Locus ID:

NCBI: 10498
MIM: 603934
HGNC: 23393
Ensembl: ENSG00000142453

Variants:

dbSNP: 10498
ClinVar: 10498
TCGA: ENSG00000142453
COSMIC: CARM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142453ENST00000327064Q86X55
ENSG00000142453ENST00000344150Q86X55
ENSG00000142453ENST00000586221K7EQA8
ENSG00000142453ENST00000586298K7EQB9
ENSG00000142453ENST00000588947K7EK20
ENSG00000142453ENST00000589693K7ERM3
ENSG00000142453ENST00000590039K7EIQ8
ENSG00000142453ENST00000590699K7EPK1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108
RORA activates gene expressionREACTOMER-HSA-1368082
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
RMTs methylate histone argininesREACTOMER-HSA-3214858
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestREACTOMER-HSA-6804114
Endocrine resistanceKEGGko01522
Endocrine resistanceKEGGhsa01522

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382239782024Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1.0
386493672024Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity.0
388782782024Protein Arginine Methyltransferase CARM1 in Human Breast Cancer.0
389276362024Trans-Activation of the Coactivator-Associated Arginine Methyltransferase 1 (Carm1) Gene by the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 1.0
382239782024Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1.0
386493672024Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity.0
388782782024Protein Arginine Methyltransferase CARM1 in Human Breast Cancer.0
389276362024Trans-Activation of the Coactivator-Associated Arginine Methyltransferase 1 (Carm1) Gene by the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 1.0
353546452023Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis.4
371967822023Unraveling the complexity of histone-arginine methyltransferase CARM1 in cancer: From underlying mechanisms to targeted therapeutics.0
372166432023PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ.1
373658882023Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity.0
374777992023Inhibition of CARM1 suppresses proliferation of multiple myeloma cells through activation of p53 signaling pathway.0
379951782023BACH1 regulates the differentiation of vascular smooth muscle cells from human embryonic stem cells via CARM1-mediated methylation of H3R17.0
353546452023Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis.4

Citation

Dessen P

CARM1 (coactivator associated arginine methyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43874/carm1-(coactivator-associated-arginine-methyltransferase-1)