ITCH (itchy E3 ubiquitin protein ligase)

2007-02-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
ADMFD,AIF4,AIP4,NAPP1
FUSION GENES

Other Information

Locus ID:

NCBI: 83737
MIM: 606409
HGNC: 13890
Ensembl: ENSG00000078747

Variants:

dbSNP: 83737
ClinVar: 83737
TCGA: ENSG00000078747
COSMIC: ITCH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078747ENST00000262650Q96J02
ENSG00000078747ENST00000374864Q96J02
ENSG00000078747ENST00000461661A0A1W2PNZ8
ENSG00000078747ENST00000486883A0A1W2PR79
ENSG00000078747ENST00000535650Q96J02
ENSG00000078747ENST00000654846A0A590UIY0
ENSG00000078747ENST00000660337A0A590UK44
ENSG00000078747ENST00000664852A0A590UK95
ENSG00000078747ENST00000665346Q96J02
ENSG00000078747ENST00000665428A0A590UJ55
ENSG00000078747ENST00000665484A0A590UJW8
ENSG00000078747ENST00000670516A0A590UJQ1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACTOMER-HSA-168643
NOD1/2 Signaling PathwayREACTOMER-HSA-168638
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Signal TransductionREACTOMER-HSA-162582
Signaling by ERBB4REACTOMER-HSA-1236394
Downregulation of ERBB4 signalingREACTOMER-HSA-1253288
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
Activated NOTCH1 Transmits Signal to the NucleusREACTOMER-HSA-2122948
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'off' stateREACTOMER-HSA-5610787
Degradation of GLI1 by the proteasomeREACTOMER-HSA-5610780
Hedgehog 'on' stateREACTOMER-HSA-5632684

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
146020722003The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4.159
198815092009PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4.122
171150282006Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.116
156781062005The ubiquitin-protein ligase Itch regulates p73 stability.111
276425892016Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/β-Catenin Pathway.106
293860152018Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression.97
179472332007Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4.94
170285732006Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains.73
193430522009Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.64
212124142011Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity.64

Citation

Dessen P

ITCH (itchy E3 ubiquitin protein ligase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43875/itch-(itchy-e3-ubiquitin-protein-ligase)