CDK5RAP3 (CDK5 regulatory subunit associated protein 3)

2007-02-01  

Identity

HGNC
CDK5RAP3
LOCATION
17q21.32
LOCUSID
80279
ALIAS
C53,HSF-27,IC53,LZAP,MST016,OK/SW-cl.114,PP1553
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80279
MIM: 608202
HGNC: 18673
Ensembl: ENSG00000108465

Variants:

dbSNP: 80279
ClinVar: 80279
TCGA: ENSG00000108465
COSMIC: CDK5RAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108465ENST00000338399Q96JB5
ENSG00000108465ENST00000536708Q96JB5
ENSG00000108465ENST00000577664J3QRX0
ENSG00000108465ENST00000578018J3KTA5
ENSG00000108465ENST00000578525J3KS63
ENSG00000108465ENST00000579175J3QQY1
ENSG00000108465ENST00000579605J3KRK4
ENSG00000108465ENST00000579632J3QS62
ENSG00000108465ENST00000580391J3QQS7
ENSG00000108465ENST00000580670J3QL95
ENSG00000108465ENST00000583352J3QL86
ENSG00000108465ENST00000583363J3KSD0
ENSG00000108465ENST00000583697J3QRM1
ENSG00000108465ENST00000584991J3KRI2

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387258602024TSPAN6 reinforces the malignant progression of glioblastoma via interacting with CDK5RAP3 and regulating STAT3 signaling pathway.1
387258602024TSPAN6 reinforces the malignant progression of glioblastoma via interacting with CDK5RAP3 and regulating STAT3 signaling pathway.1
359993592023CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages.4
359993592023CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages.4
352196402022CDK5RAP3 acts as a putative tumor inhibitor in papillary thyroid carcinoma via modulation of Akt/GSK-3β/Wnt/β-catenin signaling.1
352196402022CDK5RAP3 acts as a putative tumor inhibitor in papillary thyroid carcinoma via modulation of Akt/GSK-3β/Wnt/β-catenin signaling.1
326063582020CDK5RAP3 as tumour suppressor negatively regulates self-renewal and invasion and is regulated by ERK1/2 signalling in human gastric cancer.7
326063582020CDK5RAP3 as tumour suppressor negatively regulates self-renewal and invasion and is regulated by ERK1/2 signalling in human gastric cancer.7
308647002019Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3β/cyclin D1 signaling pathway.11
309544482019C53: A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti-fibrotic actions in human cardiac and renal fibroblasts.17
310616822019CDK5RAP3 Participates in Autophagy Regulation and Is Downregulated in Renal Cancer.5
308647002019Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3β/cyclin D1 signaling pathway.11
309544482019C53: A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti-fibrotic actions in human cardiac and renal fibroblasts.17
310616822019CDK5RAP3 Participates in Autophagy Regulation and Is Downregulated in Renal Cancer.5
295401962018CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer.24

Citation

Dessen P

CDK5RAP3 (CDK5 regulatory subunit associated protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43880/cdk5rap3-(cdk5-regulatory-subunit-associated-protein-3)