SPON1 (spondin 1)

2007-02-01  

Identity

HGNC
LOCATION
11p15.2
LOCUSID
ALIAS
VSGP/F-spondin,f-spondin
FUSION GENES

Other Information

Locus ID:

NCBI: 10418
MIM: 604989
HGNC: 11252
Ensembl: ENSG00000262655

Variants:

dbSNP: 10418
ClinVar: 10418
TCGA: ENSG00000262655
COSMIC: SPON1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000262655ENST00000576479Q9HCB6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-glycosylation of TSR domain-containing proteinsREACTOMER-HSA-5173214
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective B3GALTL causes Peters-plus syndrome (PpS)REACTOMER-HSA-5083635

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371793552023SPON1 is an independent prognostic biomarker for ovarian cancer.0
371793552023SPON1 is an independent prognostic biomarker for ovarian cancer.0
354877602022Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.3
354877602022Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.3
319277442021Prognostic and Diagnostic Values of miR-506 and SPON 1 in Colorectal Cancer with Clinicopathological Considerations.7
319277442021Prognostic and Diagnostic Values of miR-506 and SPON 1 in Colorectal Cancer with Clinicopathological Considerations.7
324847212020Evaluation of relationship between SPON1 gene and genetic susceptibility of postmenopausal osteoporosis.4
324847212020Evaluation of relationship between SPON1 gene and genetic susceptibility of postmenopausal osteoporosis.4
295730412018APOE influences working memory in non-demented elderly through an interaction with SPON1 rs2618516.8
295730412018APOE influences working memory in non-demented elderly through an interaction with SPON1 rs2618516.8
270107272016Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients.29
270107272016Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients.29
260324982015Spondin 1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma.17
260324982015Spondin 1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma.17
235350332014Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.94

Citation

Dessen P

SPON1 (spondin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43886/spon1-(spondin-1)