Identity
HGNC
LOCATION
5q32
LOCUSID
ALIAS
LEKTI,LETKI,NETS,NS,VAKTI
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11005
MIM: 605010
HGNC: 15464
Ensembl: ENSG00000133710
Variants:
dbSNP: 11005
ClinVar: 11005
TCGA: ENSG00000133710
COSMIC: SPINK5
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Keratinization | REACTOME | R-HSA-6805567 |
| Formation of the cornified envelope | REACTOME | R-HSA-6809371 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37071303 | 2024 | Inhibition of the Tumor Suppressor Gene SPINK5 via EHMT2 Induces the Oral Squamous Cell Carcinoma Development. | 3 |
| 38316920 | 2024 | Comparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice uncover disease-relevant pathways. | 0 |
| 38442944 | 2024 | SPINK5 inhibits esophageal squamous cell carcinoma metastasis via immune activity. | 0 |
| 37071303 | 2024 | Inhibition of the Tumor Suppressor Gene SPINK5 via EHMT2 Induces the Oral Squamous Cell Carcinoma Development. | 3 |
| 38316920 | 2024 | Comparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice uncover disease-relevant pathways. | 0 |
| 38442944 | 2024 | SPINK5 inhibits esophageal squamous cell carcinoma metastasis via immune activity. | 0 |
| 32709676 | 2021 | Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5 variants. | 14 |
| 32709676 | 2021 | Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5 variants. | 14 |
| 31407378 | 2020 | Exonic mutations associated with atopic dermatitis disrupt lympho-epithelial Kazal-type related inhibitor action and enhance its degradation. | 4 |
| 32564679 | 2020 | MiR-375-3p alleviates the severity of inflammation through targeting YAP1/LEKTI pathway in HaCaT cells. | 10 |
| 32664181 | 2020 | Genetic polymorphisms in serine protease inhibitor Kazal-type 5 and risk of atopic dermatitis: A meta-analysis. | 3 |
| 31407378 | 2020 | Exonic mutations associated with atopic dermatitis disrupt lympho-epithelial Kazal-type related inhibitor action and enhance its degradation. | 4 |
| 32564679 | 2020 | MiR-375-3p alleviates the severity of inflammation through targeting YAP1/LEKTI pathway in HaCaT cells. | 10 |
| 32664181 | 2020 | Genetic polymorphisms in serine protease inhibitor Kazal-type 5 and risk of atopic dermatitis: A meta-analysis. | 3 |
| 30801672 | 2019 | LEKTI domains D6, D7 and D8+9 serve as substrates for transglutaminase 1: implications for targeted therapy of Netherton syndrome. | 3 |
Citation
Dessen P
SPINK5 (serine peptidase inhibitor Kazal type 5)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43889/spink5-(serine-peptidase-inhibitor-kazal-type-5)
