GREM1 (gremlin 1, DAN family BMP antagonist)

2007-02-01  

Identity

HGNC
GREM1
LOCATION
15q13.3
LOCUSID
26585
ALIAS
C15DUPq,CKTSF1B1,CRAC1,CRCS4,DAND2,DRM,DUP15q,GREMLIN,HMPS,HMPS1,IHG-2,MPSH,PIG2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26585
MIM: 603054
HGNC: 2001
Ensembl: ENSG00000166923

Variants:

dbSNP: 26585
ClinVar: 26585
TCGA: ENSG00000166923
COSMIC: GREM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166923ENST00000560677H0YLY2
ENSG00000166923ENST00000560830O60565
ENSG00000166923ENST00000651154O60565
ENSG00000166923ENST00000651154A6XAA7
ENSG00000166923ENST00000652365O60565
ENSG00000166923ENST00000652365A6XAA7

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
379315342024GREM1 knockdown regulates the proliferation, apoptosis and EMT of benign prostatic hyperplasia by suppressing the STAT3/c-Myc signaling.0
382501542024Angiogenic and Fibrogenic Dual-effect of Gremlin1 on Proliferative Diabetic Retinopathy.0
384513112024BMP4 and GREM1 are targets of SHH signaling and downstream regulators of collagen in the penis.0
384513212024SHH regulates penile morphology and smooth muscle through a mechanism involving BMP4 and GREM1.0
385246342024Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis.2
379315342024GREM1 knockdown regulates the proliferation, apoptosis and EMT of benign prostatic hyperplasia by suppressing the STAT3/c-Myc signaling.0
382501542024Angiogenic and Fibrogenic Dual-effect of Gremlin1 on Proliferative Diabetic Retinopathy.0
384513112024BMP4 and GREM1 are targets of SHH signaling and downstream regulators of collagen in the penis.0
384513212024SHH regulates penile morphology and smooth muscle through a mechanism involving BMP4 and GREM1.0
385246342024Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis.2
333705492023Resistance training, gremlin 1 and macrophage migration inhibitory factor in obese men: a randomised trial.8
361551652023Role of gremlin-1 in the pathophysiology of the adipose tissues.1
367884082023Recent Advancements in Gremlin-1: Breast cancer.0
368005882023TCF7L2, CASC8, and GREM1 polymorphism and colorectal cancer in south-eastern Romanian population.0
368044262023circRNA-ZCCHC14 affects the chondrogenic differentiation ability of peripheral blood-derived mesenchymal stem cells by regulating GREM1 through miR-181a.0

Citation

Dessen P

GREM1 (gremlin 1, DAN family BMP antagonist)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43901/grem1-(gremlin-1-dan-family-bmp-antagonist)