Identity
HGNC
LOCATION
2q33.2
LOCUSID
ALIAS
ALPS5,CD,CD152,CELIAC3,CTLA-4,GRD4,GSE,IDDM12
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1493
MIM: 123890
HGNC: 2505
Ensembl: ENSG00000163599
Variants:
dbSNP: 1493
ClinVar: 1493
TCGA: ENSG00000163599
COSMIC: CTLA4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000163599 | ENST00000295854 | P16410 |
| ENSG00000163599 | ENST00000472206 | P16410 |
| ENSG00000163599 | ENST00000487393 | P16410 |
| ENSG00000163599 | ENST00000648405 | P16410 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10252 | bortezomib | Chemical | ClinicalAnnotation | associated | PD | 21228734 | |
| PA164712462 | Antiinflammatory agents, non-steroids | Chemical | ClinicalAnnotation | associated | PD | 28750137 | |
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation | associated | PD | 26194362 | |
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PK | PD | 18021981 |
| PA445451 | Psoriasis | Disease | ClinicalAnnotation | associated | PD | 26194362 | |
| PA449167 | cyclosporine | Chemical | ClinicalAnnotation | associated | PD | 18021981 | |
| PA449247 | dexamethasone | Chemical | ClinicalAnnotation | associated | PD | 21228734 | |
| PA450354 | melphalan | Chemical | ClinicalAnnotation | associated | PD | 21228734 | |
| PA451100 | prednisone | Chemical | ClinicalAnnotation | associated | PD | 21228734 | |
| PA451578 | tacrolimus | Chemical | ClinicalAnnotation | associated | PK |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36918273 | 2024 | Implications of LAG3 and CTLA4 immune checkpoints beyond PD-1/PD-L1 as a potential target in determining the prognosis of uveal melanoma patients. | 3 |
| 37679967 | 2024 | Association between CTLA4 + 49A/G polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis. | 0 |
| 38042220 | 2024 | Dual silencing of tumor-intrinsic VISTA and CTLA-4 stimulates T-cell mediated immune responses and inhibits MCF7 breast cancer development. | 1 |
| 38180994 | 2024 | Detection of CTLA-4 level and humeral immune response after the second dose of COVID-19 vaccine in certain Iraqi provinces participants. | 0 |
| 38417442 | 2024 | Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells. | 3 |
| 38520576 | 2024 | CTLA-4 expression and polymorphisms in Schizophrenia; a systematic review of literature. | 0 |
| 38536023 | 2024 | TIM3 and CTLA4 immune checkpoint polymorphisms are associated with acute myeloid leukemia in Saudi Arabia. | 0 |
| 38723011 | 2024 | Association of tuberculosis risk with genetic polymorphisms of the immune checkpoint genes PDCD1, CTLA-4, and TIM3. | 0 |
| 38852289 | 2024 | Targeting the dynamic transcriptional landscape of Treg subpopulations in pancreatic ductal adenocarcinoma: Insights from single-cell RNA sequencing analysis with a focus on CTLA4 and TIGIT. | 0 |
| 38867048 | 2024 | CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation. | 0 |
| 38955918 | 2024 | CTLA-4 silencing could promote anti-tumor effects in hepatocellular. | 0 |
| 36918273 | 2024 | Implications of LAG3 and CTLA4 immune checkpoints beyond PD-1/PD-L1 as a potential target in determining the prognosis of uveal melanoma patients. | 3 |
| 37679967 | 2024 | Association between CTLA4 + 49A/G polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis. | 0 |
| 38042220 | 2024 | Dual silencing of tumor-intrinsic VISTA and CTLA-4 stimulates T-cell mediated immune responses and inhibits MCF7 breast cancer development. | 1 |
| 38180994 | 2024 | Detection of CTLA-4 level and humeral immune response after the second dose of COVID-19 vaccine in certain Iraqi provinces participants. | 0 |
Citation
Dessen P
CTLA4 (cytotoxic T-lymphocyte associated protein 4)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43902/ctla4-(cytotoxic-t-lymphocyte-associated-protein-4)
