CHIT1 (chitinase 1)

2007-02-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
CHI3,CHIT,CHITD
FUSION GENES

Other Information

Locus ID:

NCBI: 1118
MIM: 600031
HGNC: 1936
Ensembl: ENSG00000133063

Variants:

dbSNP: 1118
ClinVar: 1118
TCGA: ENSG00000133063
COSMIC: CHIT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133063ENST00000255427Q13231
ENSG00000133063ENST00000367229Q13231
ENSG00000133063ENST00000491855Q13231
ENSG00000133063ENST00000503786D6REY1

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Amino sugar and nucleotide sugar metabolismKEGGko00520
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
188453282008Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit.46
196443632009The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases.42
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.30
228263222012Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-β1 signaling.26
263726802016Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease.26
170756952006Chitotriosidase: the yin and yang.24
207977812010Human macrophage activation triggered by chitotriosidase-mediated chitin and chitosan degradation.21
211597212011Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis.21
128936882003Serum chitotriosidase activity is increased in subjects with atherosclerosis disease.20

Citation

Dessen P

CHIT1 (chitinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43912/chit1-(chitinase-1)