ADCYAP1R1 (ADCYAP receptor type I)

2007-02-01  

Identity

HGNC
LOCATION
7p14.3
LOCUSID
ALIAS
PAC1,PAC1R,PACAPR,PACAPRI
FUSION GENES

Other Information

Locus ID:

NCBI: 117
MIM: 102981
HGNC: 242
Ensembl: ENSG00000078549

Variants:

dbSNP: 117
ClinVar: 117
TCGA: ENSG00000078549
COSMIC: ADCYAP1R1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078549ENST00000304166P41586
ENSG00000078549ENST00000304166A0A090N8F8
ENSG00000078549ENST00000396211P41586
ENSG00000078549ENST00000409363P41586
ENSG00000078549ENST00000409489E9PFU5
ENSG00000078549ENST00000431811C9JVH3
ENSG00000078549ENST00000436116H0Y813
ENSG00000078549ENST00000614107P41586

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Insulin secretionKEGGhsa04911
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Activation of TRKA receptorsREACTOMER-HSA-187015
NGF-independant TRKA activationREACTOMER-HSA-187024
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
213504822011Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor.270
174708062007Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.50
235052602013ADCYAP1R1 genotype associates with post-traumatic stress symptoms in highly traumatized African-American females.41
245161272014PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus.41
164016442006The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein.36
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
232809522013Adcyap1r1 genotype, posttraumatic stress disorder, and depression among women exposed to childhood maltreatment.34
233285282013ADCYAP1R1 and asthma in Puerto Rican children.33
227768992013PAC1 receptor (ADCYAP1R1) genotype is associated with dark-enhanced startle in children.30
259188342015Stress and Bronchodilator Response in Children with Asthma.28

Citation

Dessen P

ADCYAP1R1 (ADCYAP receptor type I)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43913/adcyap1r1-(adcyap-receptor-type-i)