Identity
HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
OCT3,OCT4,OTF-3,OTF3,OTF4,Oct-3,Oct-4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5460
MIM: 164177
HGNC: 9221
Ensembl: ENSG00000204531
Variants:
dbSNP: 5460
ClinVar: 5460
TCGA: ENSG00000204531
COSMIC: POU5F1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166120929 | severe cutaneous adverse reactions | Disease | ClinicalAnnotation | associated | PD | 21801394 | |
| PA444059 | Epidermal Necrolysis, Toxic | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 21801394 | |
| PA445738 | Stevens-Johnson Syndrome | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 21801394 | |
| PA448320 | allopurinol | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 21801394 | |
| PA448785 | carbamazepine | Chemical | VariantAnnotation | associated | PD | ||
| PA450947 | phenytoin | Chemical | VariantAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37917979 | 2024 | The m6A reader IGF2BP2 promotes the progression of esophageal squamous cell carcinoma cells by increasing the stability of OCT4 mRNA. | 0 |
| 38233795 | 2024 | UTP11 promotes the growth of hepatocellular carcinoma by enhancing the mRNA stability of Oct4. | 0 |
| 38254118 | 2024 | A positive feedback between PDIA3P1 and OCT4 promotes the cancer stem cell properties of esophageal squamous cell carcinoma. | 3 |
| 38421873 | 2024 | Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes. | 0 |
| 38430256 | 2024 | Oct4 activates IL-17A to orchestrate M2 macrophage polarization and cervical cancer metastasis. | 0 |
| 38486279 | 2024 | Sox9 downregulation in non-obstructive azoospermia by UTF1 and mediator role of POU5F1. | 0 |
| 38579716 | 2024 | Oct4 controls basement membrane development during human embryogenesis. | 0 |
| 38928444 | 2024 | LINC00662 Promotes Aggressive Traits by Modulating OCT4 Expression through miR-335-5p in Gallbladder Cancer Cells. | 0 |
| 37917979 | 2024 | The m6A reader IGF2BP2 promotes the progression of esophageal squamous cell carcinoma cells by increasing the stability of OCT4 mRNA. | 0 |
| 38233795 | 2024 | UTP11 promotes the growth of hepatocellular carcinoma by enhancing the mRNA stability of Oct4. | 0 |
| 38254118 | 2024 | A positive feedback between PDIA3P1 and OCT4 promotes the cancer stem cell properties of esophageal squamous cell carcinoma. | 3 |
| 38421873 | 2024 | Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes. | 0 |
| 38430256 | 2024 | Oct4 activates IL-17A to orchestrate M2 macrophage polarization and cervical cancer metastasis. | 0 |
| 38486279 | 2024 | Sox9 downregulation in non-obstructive azoospermia by UTF1 and mediator role of POU5F1. | 0 |
| 38579716 | 2024 | Oct4 controls basement membrane development during human embryogenesis. | 0 |
Citation
Dessen P
POU5F1 (POU class 5 homeobox 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43916/pou5f1-(pou-class-5-homeobox-1)
