ARG1 (arginase 1)

2007-02-01 Affiliation

Identity

HGNC

ARG1

LOCATION

6q23.2

LOCUSID

383

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 383
MIM: 608313
HGNC: 663
Ensembl: ENSG00000118520

Variants:

dbSNP: 383
ClinVar: 383
TCGA: ENSG00000118520
COSMIC: ARG1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000118520	ENST00000356962	P05089
ENSG00000118520	ENST00000368087	P05089
ENSG00000118520	ENST00000640973	P05089

Expression (GTEx)

100

150

200

250

300

350

400

450

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arginine biosynthesis	KEGG	ko00220
Arginine and proline metabolism	KEGG	ko00330
Arginine biosynthesis	KEGG	hsa00220
Arginine and proline metabolism	KEGG	hsa00330
Metabolic pathways	KEGG	hsa01100
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Urea cycle	KEGG	hsa_M00029
Polyamine biosynthesis, arginine => ornithine => putrescine	KEGG	hsa_M00134
Urea cycle	KEGG	M00029
Polyamine biosynthesis, arginine => ornithine => putrescine	KEGG	M00134
Biosynthesis of amino acids	KEGG	hsa01230
Biosynthesis of amino acids	KEGG	ko01230
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Urea cycle	REACTOME	R-HSA-70635
Metabolism of polyamines	REACTOME	R-HSA-351202
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD
PA134687887	selective beta-2-adrenoreceptor agonists	Chemical	ClinicalAnnotation	associated	PD
PA166176020	sodium benzoate / sodium phenylacetate	Chemical	LabelAnnotation	associated
PA443450	Asthma	Disease	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
15998894	2005	Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.	218
17255300	2007	Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma.	172
23454751	2013	STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients.	156
19508396	2009	Recent advances in arginine metabolism: roles and regulation of the arginases.	128
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16709958	2006	Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis.	80
19286931	2009	Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma.	46
10542097	1999	Arginase-boronic acid complex highlights a physiological role in erectile function.	45
19801451	2009	Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase.	44

Citation

Dessen P

ARG1 (arginase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43917/arg1-(arginase-1)