CS (citrate synthase)

2007-02-01 Affiliation

Identity

HGNC

LOCATION

12q13.3

LOCUSID

1431

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1431
MIM: 118950
HGNC: 2422
Ensembl: ENSG00000062485

Variants:

dbSNP: 1431
ClinVar: 1431
TCGA: ENSG00000062485
COSMIC: CS

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000062485	ENST00000351328	O75390
ENSG00000062485	ENST00000351328	A0A024RB75
ENSG00000062485	ENST00000542324	B4DJV2
ENSG00000062485	ENST00000546891	H0YH82
ENSG00000062485	ENST00000546930	F8VR34
ENSG00000062485	ENST00000547298	F8VRP1
ENSG00000062485	ENST00000548041	F8VTT8
ENSG00000062485	ENST00000548567	A0A0C4DGI3
ENSG00000062485	ENST00000548746	H0YIC4
ENSG00000062485	ENST00000548849	F8VWQ5
ENSG00000062485	ENST00000549143	F8VVY4
ENSG00000062485	ENST00000549221	F8VRI6
ENSG00000062485	ENST00000550159	F8VZK9
ENSG00000062485	ENST00000550655	F8W4S1
ENSG00000062485	ENST00000550734	F8VPA1
ENSG00000062485	ENST00000551137	F8VX07
ENSG00000062485	ENST00000551253	F8VPF9
ENSG00000062485	ENST00000551430	F8W642
ENSG00000062485	ENST00000551473	F8VX68
ENSG00000062485	ENST00000551936	F8VPA1
ENSG00000062485	ENST00000551968	F8VU34
ENSG00000062485	ENST00000552222	F8W0J2
ENSG00000062485	ENST00000552688	F8W1S4

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Citrate cycle (TCA cycle)	KEGG	ko00020
Glyoxylate and dicarboxylate metabolism	KEGG	ko00630
Citrate cycle (TCA cycle)	KEGG	hsa00020
Glyoxylate and dicarboxylate metabolism	KEGG	hsa00630
Metabolic pathways	KEGG	hsa01100
Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate	KEGG	hsa_M00010
Citrate cycle (TCA cycle, Krebs cycle)	KEGG	M00009
Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate	KEGG	M00010
2-Oxocarboxylic acid metabolism	KEGG	hsa01210
2-Oxocarboxylic acid metabolism	KEGG	ko01210
Biosynthesis of amino acids	KEGG	hsa01230
Biosynthesis of amino acids	KEGG	ko01230
Carbon metabolism	KEGG	hsa01200
Carbon metabolism	KEGG	ko01200
Citrate cycle (TCA cycle, Krebs cycle)	KEGG	hsa_M00009
Metabolism of proteins	REACTOME	R-HSA-392499
Mitochondrial protein import	REACTOME	R-HSA-1268020
Metabolism	REACTOME	R-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transport	REACTOME	R-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycle	REACTOME	R-HSA-71406
Citric acid cycle (TCA cycle)	REACTOME	R-HSA-71403

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
23139858	2012	Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy.	44
27179829	2016	Skeletal Muscle Mitochondrial Content, Oxidative Capacity, and Mfn2 Expression Are Reduced in Older Patients With Heart Failure and Preserved Ejection Fraction and Are Related to Exercise Intolerance.	30
12531911	2003	Citrate synthase expression and enzyme activity after endurance training in cardiac and skeletal muscles.	27
15714131	2005	Enhanced citrate synthase activity in human pancreatic cancer.	20
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	17
19479947	2009	Identification and characterization of the mitochondrial targeting sequence and mechanism in human citrate synthase.	9
22485150	2012	Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα).	9
28391595	2017	Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase.	8
27363021	2016	Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinoma.	7
28161643	2017	SIRT3 deacetylated and increased citrate synthase activity in PD model.	6

Citation

Dessen P

CS (citrate synthase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43924/cs-(citrate-synthase)