IL23R (interleukin 23 receptor)

2007-02-01 Affiliation

Identity

HGNC

IL23R

LOCATION

1p31.3

LOCUSID

149233

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 149233
MIM: 607562
HGNC: 19100
Ensembl: ENSG00000162594

Variants:

dbSNP: 149233
ClinVar: 149233
TCGA: ENSG00000162594
COSMIC: IL23R

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000162594	ENST00000347310	Q5VWK5
ENSG00000162594	ENST00000395227	Q5VWK5
ENSG00000162594	ENST00000425614	Q5VWK5
ENSG00000162594	ENST00000473881	A0A0D9SFJ7
ENSG00000162594	ENST00000637002	A0A1B0GV19

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Jak-STAT signaling pathway	KEGG	ko04630
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Jak-STAT signaling pathway	KEGG	hsa04630
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164713366	Tumor necrosis factor alpha (TNF-alpha) inhibitors	Chemical	ClinicalAnnotation	associated	PD	26194362
PA445451	Psoriasis	Disease	ClinicalAnnotation	associated	PD	26194362
PA446108	Colorectal Neoplasms	Disease	ClinicalAnnotation	associated	PD	23778325
PA448871	celecoxib	Chemical	ClinicalAnnotation	associated	PD	23778325

References

Pubmed ID	Year	Title	Citations
17068223	2006	A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.	887
17068223	2006	A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.	887
17435756	2007	Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.	632
17952073	2007	Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.	428
19169254	2009	Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.	410
19169254	2009	Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.	410
17236132	2007	A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.	285
17236132	2007	A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.	285
18369459	2008	A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.	192
17447842	2007	Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.	183

Citation

Dessen P

IL23R (interleukin 23 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43925/il23r-(interleukin-23-receptor)