SOAT1 (sterol O-acyltransferase 1)

2007-02-01  

Identity

HGNC
SOAT1
LOCATION
1q25.2
LOCUSID
6646
ALIAS
ACACT,ACAT,ACAT-1,ACAT1,SOAT,STAT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6646
MIM: 102642
HGNC: 11177
Ensembl: ENSG00000057252

Variants:

dbSNP: 6646
ClinVar: 6646
TCGA: ENSG00000057252
COSMIC: SOAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000057252ENST00000367619P35610
ENSG00000057252ENST00000426956B1APM4
ENSG00000057252ENST00000539888P35610
ENSG00000057252ENST00000540564P35610

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Steroid biosynthesisKEGGko00100
Steroid biosynthesisKEGGhsa00100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
LDL-mediated lipid transportREACTOMER-HSA-171052

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386738032024Sterol O-Acyltransferase 1 (SOAT1): A Genetic Modifier of Niemann-Pick Disease, Type C1.0
387244992024SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma.0
387709382024SOAT1 in gallbladder cancer: Clinicopathological significance and avasimibe therapeutics.0
386738032024Sterol O-Acyltransferase 1 (SOAT1): A Genetic Modifier of Niemann-Pick Disease, Type C1.0
387244992024SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma.0
387709382024SOAT1 in gallbladder cancer: Clinicopathological significance and avasimibe therapeutics.0
343264742022High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer.9
344600582022SOAT1 is a new prognostic factor of colorectal cancer.2
346701022022SOAT1 enhances lung cancer invasiveness by stimulating AKT-mediated mitochondrial fragmentation.6
353541202022piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure.9
354090862022SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma?6
359416082022High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth.7
343264742022High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer.9
344600582022SOAT1 is a new prognostic factor of colorectal cancer.2
346701022022SOAT1 enhances lung cancer invasiveness by stimulating AKT-mediated mitochondrial fragmentation.6

Citation

Dessen P

SOAT1 (sterol O-acyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43926/soat1-(sterol-o-acyltransferase-1)