TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1)

2007-02-01  

Identity

HGNC
TIAL1
LOCATION
10q26.11
LOCUSID
7073
ALIAS
TCBP,TIAR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7073
MIM: 603413
HGNC: 11804
Ensembl: ENSG00000151923

Variants:

dbSNP: 7073
ClinVar: 7073
TCGA: ENSG00000151923
COSMIC: TIAL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151923ENST00000369086A6NKZ9
ENSG00000151923ENST00000369093Q01085
ENSG00000151923ENST00000412524E7ETJ9
ENSG00000151923ENST00000436547Q01085
ENSG00000151923ENST00000479729A0A087WX93
ENSG00000151923ENST00000497671E7ETC0

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR2REACTOMER-HSA-5654738
FGFR2 alternative splicingREACTOMER-HSA-6803529

References

Pubmed IDYearTitleCitations
376998832023RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation.2
376998832023RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation.2
305381182019TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress.14
305691362019miR‑223‑3p/TIAL1 interaction is involved in the mechanisms associated with the neuroprotective effects of dexmedetomidine on hippocampal neuronal cells in vitro.6
305381182019TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress.14
305691362019miR‑223‑3p/TIAL1 interaction is involved in the mechanisms associated with the neuroprotective effects of dexmedetomidine on hippocampal neuronal cells in vitro.6
282984742017Tumor protein D52 expression is post-transcriptionally regulated by T-cell intercellular antigen (TIA) 1 and TIA-related protein via mRNA stability.2
291492902017Discovering the 3' UTR-mediated regulation of alpha-synuclein.21
282984742017Tumor protein D52 expression is post-transcriptionally regulated by T-cell intercellular antigen (TIA) 1 and TIA-related protein via mRNA stability.2
291492902017Discovering the 3' UTR-mediated regulation of alpha-synuclein.21
269098582016LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway.36
269098582016LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway.36
263634552015TIA-1 and TIAR interact with 5'-UTR of enterovirus 71 genome and facilitate viral replication.5
263634552015TIA-1 and TIAR interact with 5'-UTR of enterovirus 71 genome and facilitate viral replication.5
245661372014HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.15

Citation

Dessen P

TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43936/tial1-(tia1-cytotoxic-granule-associated-rna-binding-protein-like-1)